Corilagin attenuates airway inflammation and collagen deposition in ovalbumin-induced asthmatic mice
Main Article Content
Keywords
airway resistance, AMPK pathway, asthma, collagen deposition, ovalbumin (OVA)
Abstract
Objective: To investigate the effects of corilagin on inflammation and collagen deposition in ovalbumin (OVA)-induced asthma mouse model and uncover the mechanism.
Methods: We constructed a mouse model of OVA-induced asthma. Enzyme-linked-immunosorbent serologic assays were conducted to detect the effects of corilagin on cytokines and Immunoglobulin E (IgE) production. Hematoxylin and eosin staining was used to show pathological features in lung tissues. Masson trichrome assay was used to examine collagen deposition. In addition, the lung function was detected by mouse lung function apparatus. Immunoblot was used to confirm the mechanism.
Results: Corilagin alleviates OVA-induced cytokine and IgE production. In addition, corilagin alleviates OVA-induced pathological changes and collagen deposition in lung tissues. Corilagin also suppressed airway resistance and lung function in mice. Mechanically, corilagin activated the adenosine monophosphate-activated protein kinase (AMPK) pathway in lung tissues.
Conclusion: Corilagin attenuates airway inflammation and collagen deposition in OVA-induced asthmatic mice via AMPK pathway.
References
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2. Lv C, Li H, Cui H, Bi Q, Wang M. Solid lipid nanoparticle delivery of rhynchophylline enhanced the efficiency of allergic asthma treatment via the upregulation of suppressor of cytokine signaling 1 by repressing the p38 signaling pathway. Bioengineered. 2021;12(1):8635-49. 10.1080/21655979.2021.1988364
3. Wang M, Li H, Zhao Y, Lv C, Zhou G. Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor-beta1-mediated Smad and mitogen-activated protein kinase signaling transductions in vivo and in vitro. Exp Ther Med. 2019;17(1):251–9. 10.3892/etm.2018.6909
4. Guo J, Zhang YY, Sun M, Xu LF. Therapeutic potential of curcumin in a rat model of dextran sulfate sodium-induced ulcerative colitis by regulating the balance of Treg/Th17 cells. Inflammation. 2022;45(6):2163–71. 10.1007/s10753-022-01678-1
5. Park BG, Lee HS, Jung SH, Hong CO, Won HJ, Park HY, et al. A 90-day repeated oral toxicity study on plantamajoside concentrate from Plantago asiatica. Phytother Res (PTR). 2007;21(12):1118–23. 10.1002/ptr.2217
6. Widowati W, Kusuma HSW, Arumwardana S, Afifah E, Wahyuni CD, Wijayanti CR, et al. Corilagin potential in inhibiting oxidative and inflammatory stress in LPS-induced murine macrophage cell lines (RAW 264.7). Iran J Basic Med Sci. 2021;24(12):1656–65. 10.22038/IJBMS.2021.59348.13174
7. Liao M, Zhang R, Wang Y, Mao Z, Wu J, Guo H, et al. Corilagin prevents non-alcoholic fatty liver disease via improving lipid metabolism and glucose homeostasis in high fat diet-fed mice. Front Nutr. 2022;9:983450. 10.3389/fnut.2022.983450
8. Liu FC, Lee HC, Liao CC, Chou AH, Yu HP. Role of NADPH oxidase-derived ROS-mediated IL-6/STAT3 and MAPK/NF-kappaB signaling pathways in protective effect of corilagin against acetaminophen-induced liver injury in mice. Biology. 2023; 12(2):334. 10.3390/biology12020334.
9. Meng D, Deng X, Wu Y, Wu J, Zhang Y, Zhang J, et al. Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFkappaB/MAPK pathway. Heliyon. 2023; 9(6):e16960. 10.1016/j.heliyon.2023.e16960
10. Yang MH, Baek SH, Hwang ST, Um JY, Ahn KS. Corilagin exhibits differential anticancer effects through the modulation of STAT3/5 and MAPKs in human gastric cancer cells. Phytother Res (PTR). 2022;36(6):2449–62. 10.1002/ptr.7419
11. Huang WC, Liou CJ, Shen SC, Hu S, Chao JC, Hsiao CY, et al. Urolithin A inactivation of TLR3/TRIF signaling to block the NF-kappaB/STAT1 axis reduces inflammation and enhances antioxidant defense in Poly(I:C)-induced RAW264.7 cells. Int J Mol Sci. 2022;23(9):4697. 10.3390/ijms23094697.
12. Pooladanda V, Thatikonda S, Bale S, Pattnaik B, Sigalapalli DK, Bathini NB, et al. Nimbolide protects against endotoxin--induced acute respiratory distress syndrome by inhibiting TNF-alpha mediated NF-kappaB and HDAC-3 nuclear translocation. Cell Death Dis. 2019;10(2):81. 10.1038/s41419-018-1247-9
13. Song X, Qian Y. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal. 2013;25(12):2335–47. 10.1016/j.cellsig.2013.07.021
14. Li T, Zhou Y, Li D, Zeng Z, Zhang S. The role of genome-scale leukocyte long noncoding RNA in identifying acute aortic dissection. Signa Vitae. 2022;18(3):101–10. 10.22514/sv.2022.030
15. Luan Y, Jin Y, Zhang P, Li H, Yang Y. Mitochondria-associated endoplasmic reticulum membranes and cardiac hypertrophy: Molecular mechanisms and therapeutic targets. Front Cardiovasc Med. 2022;9:1015722. 10.3389/fcvm.2022.1015722
16. Tan S, Su Y, Huang L, Deng S, Yan G, Yang X, et al. Corilagin attenuates osteoclastic osteolysis by enhancing HO-1 and inhibiting ROS. J Biochem Mol Toxicol. 2022;36(7):e23049. 10.1002/jbt.23049
17. Guan S, Miao F, Wang D, Hu J, Wang H. Corilagin attenuates morphine-induced BV2 microglial activation and inflammation via regulating TLR2-mediated endoplasmic reticulum stress. J Toxicol Sci. 2023;48(7):387–98. 10.2131/jts.48.387
18. Li B, Li W, Zheng M, Wang Y, Diao Y, Mou X, et al. Corilagin alleviates intestinal ischemia/reperfusion injury by relieving oxidative stress and apoptosis via AMPK/Sirt1-autophagy pathway. Exp Biol Med. 2023;248(4):317–26. 10.1177/15353702221147560
19. Wang Y, Huang S, Kong W, Wu C, Zeng T, Xie S, et al. Corilagin alleviates liver fibrosis in zebrafish and mice by repressing IDO1-mediated M2 macrophage repolarization. Phytomed Int J Phytother Phytopharmacol. 2023;119:155016. 10.1016/j.phymed.2023.155016.
20. Luo T, Zhou X, Qin M, Lin Y, Lin J, Chen G, et al. Corilagin restrains NLRP3 inflammasome activation and pyroptosis through the ROS/TXNIP/NLRP3 pathway to prevent inflammation. Oxidative Med Cell Long. 2022;2022:1652244. 10.1155/2022/1652244
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Published
Nov 1, 2023
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How to Cite
Jin, Y., & Yi, C. (2023). Corilagin attenuates airway inflammation and collagen deposition in ovalbumin-induced asthmatic mice. Allergologia Et Immunopathologia, 51(6), 97-103. https://doi.org/10.15586/v51i6.838
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How to Cite
Jin, Y., & Yi, C. (2023). Corilagin attenuates airway inflammation and collagen deposition in ovalbumin-induced asthmatic mice. Allergologia Et Immunopathologia, 51(6), 97-103. https://doi.org/10.15586/v51i6.838