Title: Recent Advances in Food Allergies: Clinical Relevance, Cross-Reactivity, and Emerging Trends in Diagnosis and Management

Overview:

Food allergies are an increasingly prevalent and clinically significant health concern worldwide, affecting both children and adults. They describe the adverse health effects in which immunological mechanisms are involved that can be induced in sensitized subjects following dietary exposure to specific proteins in foods. They involve abnormal immune responses to specific proteins in foods, often leading to symptoms ranging from mild discomfort to severe anaphylaxis. Recent advances in food allergy research have provided deeper insights into its clinical relevance, particularly regarding the impact on patients' quality of life, diagnosis, and management. Cross-reactivity, where proteins from different allergens share structural similarities, complicates diagnosis and treatment. Emerging trends in diagnosis, such as molecular and component-resolved diagnostics, promise to improve accuracy and personalization of care. Additionally, innovative management strategies, including oral immunotherapy, epicutaneous immunotherapy, and biologics, are reshaping treatment approaches, offering hope for better outcomes. This topic explores these recent developments in food allergies, focusing on clinical implications, cross-reactivity, and emerging trends in diagnosis and management. It includes a variety of food allergens, from common allergens such as peanuts, tree nuts, milk, eggs, and wheat, to emerging allergens like fruits and vegetables, mammalian meat and milk as well as food additives.

Objectives:

This Special Issue aims to:

1. To Explore the Clinical Relevance of Food Allergies with Emphasis on Recent Advances, Anaphylaxis Epidemiology, and Involved Allergens: Examine the rising incidence of anaphylaxis associated with food allergies, including trends in its epidemiology, severity, and triggers. Identify the most common and emerging food allergens, and discuss their role in the increasing complexity of food allergy management.
2. To Examine the Mechanism and Implications of Cross-Reactivity and Co-Sensitization in Food Allergies:Review the molecular basis of cross-reactivity and co-sensitization between different food allergens and its effect on diagnosis and treatment decisions for patients especially for those with multiple food allergies.
3. To Investigate Recent Advances in Food Allergy Diagnosis: Evaluate the role of new diagnostic tools in improving the accuracy of food allergy diagnoses and personalized treatment approaches
4. To Highlight Emerging Food Allergens and Their Clinical Significance: Identify both established and newly recognized food allergens, discussing the implications of their emergence on diagnostic practices and food allergy management.
5. Evidence-Based Research in food allergies: Review recent evidence-based studies on the diagnosis and treatment of food allergies, focusing on emerging diagnostic techniques.

Keywords: Food allergies, anaphylaxis, clinical relevance, cross reactivity, Co-Sensitization, IgE sensitization, Diagnostic Accuracy

 

Guest Editors & Co-GE Details:

Dr. Roua Lajnaf (Leading GE)

Department of Biological Engineering, National Engineering School of Sfax, University of Sfax, Tunisia; Immunology Department, Habib Bourguiba University Hospital, Sfax, Tunisia; Pediatric Department, Hédi Chaker University Hospital, Sfax, Tunisia

Email: [email protected]; [email protected]

https://www.scopus.com/authid/detail.uri?authorId=57050327300

Dr. Vesna Vukicevic Lazarevic  

Special Hospital for Pulmonary Diseases, Zagreb, Croatia

Email: [email protected]     

https://orcid.org/0000-0001-8145-6840

 

Important Dates:

Manuscript Submission Open:                 10 March 2025

Manuscript Submission Deadline:           20 November 2025

 

Submission guidelines:

The journal's Guide for Authors on how to prepare a paper is available at: https://all-imm.com/index.php/aei

The APC is followed by the Journal.

Papers must be submitted electronically via https://all-imm.com/index.php/aei

To ensure that all manuscripts are correctly identified for inclusion in the special issue, it is important to select the Section “Recent Advances in Food Allergies: Clinical Relevance, Cross-Reactivity, and Emerging Trends in Diagnosis and Management”.

Any inquiries regarding the content of papers should be submitted to:

Dr. Roua Lajnaf

[email protected]