Microbiome in the primary prevention of allergic diseases and bronchial asthma
Main Article Content
Keywords
Microbiome, Asthma, Allergy, Environment, Rural, Rhinitis
Abstract
Tremendous progress in the ability to identify and test the function of microorganisms in recent years has led to a much better understanding of the role of environmental and host-microbiome in the development of immune function, allergic sensitization and asthma. In this review, the most recent findings on the relationships between environmental microbiota, respiratory, intestinal microbiome, the consequences of early-life microbial exposure type and gut-lung microbial axis and the development of asthma and atopy are summarized. The current perspective on gut and airway microbiome manipulation for the primary prevention of allergic diseases and asthma is also discussed.
References
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26. Prescott SL, Danica-Lea Larcombe D-L, Alan C, Logan AC, West C, Burks W, et al. The skin microbiome: impact of modern environments on skin ecology, barier integrity, and systemic immune programming. World Allergy Org J. 2017;10:29.
27. Lynch SV, Boushey HA. The microbiome and development of allergic disease. Curr Opin Allergy Clin Immunol. 2016;16:165-71.
28. Ho Man W, de Steenhuijsen Piters W, Bogaert D. The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Microbiol. 2017;15:259-70.
29. Smits HH, Hiemstra P, Prazeres da Costa C, Ege M, Edwards M, Garn H, et al. Microbes and asthma: opportunities for intervention. J Allergy Clin Immunol. 2016;137:690-7.
30. Herbst T, Sichelstiel A, Schär C, Yadava K, Bürki K, Cahenzli J, et al. Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med. 2011;184:198-205.
31. Conrad ML, Ferstl R, Teich R, Brand S, Blümer N, Yildirim AO, et al. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J Exp Med. 2009;206:2869-77.
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33. Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, et al. The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development. Cell Host Microbe. 2015;17:704-15.
34. Abrahamsson TR, Wu RY, Jenmalm MC. Gut microbiota and allergy: the importance of the pregnancy period. Pediatr Res. 2015;77(1-2):214-9.
35. Stokholm J, Blaser MJ, Thorsen J, Rasmussen MA, Waage J, Vinding RK, et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat Commun. 2018;9:141.
36. Frei R, Akdis M, O’Mahony L. Prebiotics, probiotics, synbiotics and the immune system: experimental data and clinical evidence. Curr Opin Gastroenterol. 2015;31:153-8.
37. Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, et al. World Allergy Organization - McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): probiotics. World Allergy Org J. 2015;8:4.
38. Cuello-Garcia C, Fiocch A, Pawankar R, Yepes JJ, Morgano GP, Zhang Y, et al. World Allergy Organization - McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): prebiotics. World Allergy Org J. 2016;9:10.
39. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20:159-66.
40. Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, Taube C, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest. 2011;121:3088-93.
41. Bokulich NA, Chung J, Battaglia T, Henderson N, Jay M, Li H, et al. Antibiotics, birth mode, and diet shape microbiome maturation during early life. Sci Transl Med. 2016; 8:343ra82.
2. Lynch S, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med. 2016;375:2369-79.
3. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project: exploring the microbial part of ourselves in a changing world. Nature. 2007;449:804-10.
4. Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S, et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001;358:1129-33.
5. Braun-Fahrländer Ch, Riedler J, Herz U, Eder W, Waser M, Grize L, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med. 2002;347:869-77.
6. Haahtela T, Laatikainen T, Alenius H, Auvinen P, Fyhrquist N, Hanski I, et al. Hunt for the origin of allergy - comparing the Finnish and Russian Karelia. Clin Exp Allergy. 2015;45:891-901.
7. Ruokolainen L, Paalanen L, Karkman A, Laatikainen T, von Hertzen L, Vlasoff T, et al. Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia. Clin Exp Allergy. 2017;47:665-74.
8. Stein M, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, et al. Innate immunity and asthma risk in Amish and Hutterite farm children. N Engl J Med. 2016;375:411-21.
9. Gozdz J, Holbreich M, Metwali N, Thorne PS, Sperling AI, Martinez FD, et al. Amish and Hutterite environmental farm products have opposite effects on experimental models of asthma. Ann Am Thorac Soc. 2016;13 Suppl. 1:S99.
10. Ege MJ, Mayer M, Normand AC, Genuneit J, Cookson WO, BraunFahrländer C, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011;364:701-9.
11. Depner M, Ege MJ, Cox MJ, Dwyer S, Walker AW, Birzele LT, et al. Bacterial microbiota of the upper respiratory tract and childhood asthma. J Allergy Clin Immunol. 2017;139:826-34.
12. Loss G, Bitter S, Wohlgensiger J, Frei R, Roduit C, Genuneit J, et al. Prenatal and early-life exposures after expression of innate immunity genes: the PASTURE cohort study. J Allergy Clin Immunol. 2012;130:523-30.
13. Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M, et al. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol. 2014;134:593-601.
14. Ober C, Sperling A, von Mutius E, Vercelli D. Immune development and environment: lessons from Amish and Hutterite children. Curr Opin Immunol. 2017;48:51-60.
15. Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science. 2015;349:1106-10.
16. Holt PG, Sly PD. Environmental microbial exposure and protection against asthma. N Engl J Med. 2015;373:2576-8.
17. Holt PG, Sly PD. Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med. 2012;18:726-35.
18. Gensollen T, Blumberg R. Correlation between early-life regulation of the immune system by microbiota and allergy development. J Allergy Clin Immunol. 2017;139:1084-91.
19. Barcik W, Pugin B, Westermann P, Perez NR, Ferst R, Wawrzyniak M, et al. Histamine-secreting microbes are increased in the gut of adult asthma patients. J Allergy Clin Immunol. 2016;138:1491-4.
20. West CE, Rydén P, Lundin D, Engstrand L, Tulic MK, Prescott SL. Gut microbiome and innate immune response patterns in IgE-associated eczema. Clin Exp Allergy. 2015;45:1419-29.
21. Lundell AC, Björnsson V, Ljung A, Ceder M, Johansen S, Lindhagen G, et al. Infant B cell memory differentiation and early gut bacterial colonization. J Immunol. 2012;188:4315-22.
22. Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J. The placenta harbors a unique microbiome. Sci Transl Med. 2014;6, 237ra65.
23. Gosalbes MJ, Llop S, Vallès Y, Moya A, Ballester F, Francino MP. Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants. Clin Exp Allergy. 2013;43:198-211.
24. Sepp E, Julge K, Vasar M, Naaber P, Björksten B, Mikelsaar M. Intestinal microflora of Estonian and Swedish infants. Acta Paediatr. 1997;86:956-61.
25. Bjorksten B, Naaber P, Sepp E, Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999;29:342-6.
26. Prescott SL, Danica-Lea Larcombe D-L, Alan C, Logan AC, West C, Burks W, et al. The skin microbiome: impact of modern environments on skin ecology, barier integrity, and systemic immune programming. World Allergy Org J. 2017;10:29.
27. Lynch SV, Boushey HA. The microbiome and development of allergic disease. Curr Opin Allergy Clin Immunol. 2016;16:165-71.
28. Ho Man W, de Steenhuijsen Piters W, Bogaert D. The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Microbiol. 2017;15:259-70.
29. Smits HH, Hiemstra P, Prazeres da Costa C, Ege M, Edwards M, Garn H, et al. Microbes and asthma: opportunities for intervention. J Allergy Clin Immunol. 2016;137:690-7.
30. Herbst T, Sichelstiel A, Schär C, Yadava K, Bürki K, Cahenzli J, et al. Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med. 2011;184:198-205.
31. Conrad ML, Ferstl R, Teich R, Brand S, Blümer N, Yildirim AO, et al. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J Exp Med. 2009;206:2869-77.
32. Huang YJ, Marshland B, Bunyavanich S, O’Mahony L, Leung DY, Muraro A, et al. The microbiome in allergic disease: current understanding and future opportunities - 2017 PRACTALL Document of the American Academy of Allergy Asthma and Immunology and the European Academy of Allergy and Clinical Immunology. J Allergy Clin Immunol. 2017;139: 1099-110.
33. Teo SM, Mok D, Pham K, Kusel M, Serralha M, Troy N, et al. The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development. Cell Host Microbe. 2015;17:704-15.
34. Abrahamsson TR, Wu RY, Jenmalm MC. Gut microbiota and allergy: the importance of the pregnancy period. Pediatr Res. 2015;77(1-2):214-9.
35. Stokholm J, Blaser MJ, Thorsen J, Rasmussen MA, Waage J, Vinding RK, et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat Commun. 2018;9:141.
36. Frei R, Akdis M, O’Mahony L. Prebiotics, probiotics, synbiotics and the immune system: experimental data and clinical evidence. Curr Opin Gastroenterol. 2015;31:153-8.
37. Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, et al. World Allergy Organization - McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): probiotics. World Allergy Org J. 2015;8:4.
38. Cuello-Garcia C, Fiocch A, Pawankar R, Yepes JJ, Morgano GP, Zhang Y, et al. World Allergy Organization - McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): prebiotics. World Allergy Org J. 2016;9:10.
39. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20:159-66.
40. Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, Taube C, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest. 2011;121:3088-93.
41. Bokulich NA, Chung J, Battaglia T, Henderson N, Jay M, Li H, et al. Antibiotics, birth mode, and diet shape microbiome maturation during early life. Sci Transl Med. 2016; 8:343ra82.
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Feb 15, 2019
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Sozanska, B. (2019). Microbiome in the primary prevention of allergic diseases and bronchial asthma. Allergologia Et Immunopathologia, 47(1), 79-84. https://all-imm.com/index.php/aei/article/view/351
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How to Cite
Sozanska, B. (2019). Microbiome in the primary prevention of allergic diseases and bronchial asthma. Allergologia Et Immunopathologia, 47(1), 79-84. https://all-imm.com/index.php/aei/article/view/351