The impact of immunomodulatory factors from maternal diet during pregnancy on cow’s milk allergy in offspring - A pilot study in the paediatric population of the Kuyavian-Pomeranian Voivodship
Main Article Content
Keywords
Cow’s milk allergy, Diet, Children, Pregnancy
Abstract
Background: The key role of dietary factors in immunotolerance promotion and allergic diseases prevention has been emphasised. The aim of the study was the analysis of the impact of immunomodulatory dietary components, consumed by pregnant women, on the development of cow’s milk allergy (CMA) in their offspring.
Materials and methods: Fifty-one pairs of mothers and their CMA-offspring were included in the study group. The analysis of a daily intake of selected dietary components was conducted retrospectively with the application of a seven-day diet of a mother in the third trimester of gestation and the authors’ own questionnaire. The Diet 5.D programme was used.
Results: An average daily retinol intake by study-group mothers was significantly lower than by control-group mothers and valued 375.6 g/d vs. 543.7 g/d (p = 0.040), respectively. Folates intake in the study group was 598.8 g/d vs. 361.1g/d in the control group (p = 0.001). Vitamin D in the study group was statistically lower- 3.6g/d, comparing to the control group - 6.9g/d (p = 0.038). Average LC-PUFA intake by mothers with allergic children was 0.09 g/d, while in the control group 0.18 g/d (p = 0.016). An analysis of the diet revealed that significantly more mothers of children from the control group (n = 12; 48%) consumed fish 2-3 times per month in comparison to the study group (n = 9; 17.6%) (p = 0.007).
Conclusions: Vitamin D, A, LC-PUFA, retinol, riboflavin and fish consumption by pregnant mothers of CMA-children was significantly lower, whereas beta-carotene and folates consumption was significantly higher than that of mothers with non-allergic children.
References
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[40].Tuokkola J, Luukkainen P, Tapanainen H, Kaila M, Vaarala O, Kenward MG, et al. Maternal diet during pregnancy and lactation and cow’s milk allergy in offspring. Eur J Clin Nutr. 2016;70:554-9.
[41]. Järvinen KM, Westfall J, De Jesus M, Mantis NJ, Carroll JA, Metzger DW, et al. Role of maternal dietary peanut exposure in development of food allergy and oral tolerance. PLoS One. 2015;10:e0143855.
[2]. Venter C, Brown KR, Maslin K, Palmer DJ. Maternal dietary intake in pregnancy and lactation and allergic diseasef outcomes in offspring. Pediatr Allergy Immunol. 2017;28:135-43.
[3]. De Filippo C. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010;107:14691-6.
[4]. Wypych TP, Marsland BJ. Diet hypotheses in light of the microbiota revolution: new perspectives. Nutrients. 2017, 9.pii:E537.
[5]. Aitoro R, Paparo L, Amoroso A, Di Costanzo M, Cosenza L, Granata V, et al. Gut microbiota as a target for preventive and therapeutic intervention against food allergy. Nutrients. 2017;9:672.
[6]. Sardecka I, Krogulska A, Toporowska-Kowalska E. The influence of dietary immunomodulatory factors on development of food allergy in children. Postepy Dermatol Alergol. 2017;34:89-96.
[7]. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157:121-41.
[8]. Tuokkola J, Luukkainen P, Kaila M, Takkinen HM, Niinistö S, Veijola R, et al. Maternal dietary folate, folic acid and vitamin D intakes during pregnancy and lactation and the risk of cows’ milk allergy in the offspring. Br J Nutr. 2016;116:710-8.
[9]. Loo EXL, Ong L, Goh A, Chia AR, Teoh OH, Colega MT, et al. Effect of maternal dietary patterns during pregnancy on self-reported allergic diseases in the first 3 years of life: results from the GUSTO study. Int Arch Allergy Immunol. 2017;173:105-13.
[10]. Nguyen AN, Elbert NJ, Pasmans SGMA, Kiefte-de Jong JC, Jong NW, Moll HA, et al. Diet quality throughout early life in relation to allergic sensitization and atopic diseases in childhood. Nutrients. 2017;9:841.
[11]. El-Gamal Y, Elmasry O, El-Ghoneimy D, Soliman I. Immunomodulatory effects of food. Egypt J Pediatr Allergy Immunol. 2011;9:3-13.
[12]. Paparo L, Constanzo M, Scala C, Cosenzal L, Leone L, Nocerino R, et al. The influence of early life nutrition on epigenetic regulatory mechanisms of the immune system. Nutrients. 2014;6:4706-19.
[13]. West CE, D’Vaz N, Prescott SL. Dietary immunomodulatory factors in the development of immune tolerance. Curr Allergy Asthma Rep. 2011;11:325-33.
[14]. Miyake Y. Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. Allergy. 2010;65:758-65.
[15]. Serhan CN, Yang R, Martin K. Maresins: novel macrofage mediator with potent anti-inflammatory and proresolving actions. J Exp Med. 2009;206:13-23.
[16]. Nurmatov U, Devereux G, Sheikh A. Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol. 2011;127:724-33.
[17]. Rochat MK, Ege MJ, Plabst D, Steinle J, Bitter S, BraunFahrländer C, et al. Maternal Vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood. Clin Exp Allergy. 2017;40:786-94.
[18]. Socha-Banasiak A, Kamer B, Gach A, Wysocka U, Jakubowski L, Głowacka E, et al. Folate status, regulatory T cells and MTHFR C677T polymorphism study in allergic children. Adv Med Sci. 2016;61:300-5.
[19]. Shaikh SR, Edidin M. Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation. Am J Clin Nutr. 2006;84:1277-89.
[20]. Bindslev-Jensen C, Ballmer-Weber BK, Bengtsson U, Blanco C, Ebner C, Hourihane J, et al. Standardization of food challenges in patients with immediate reactions to foods-position paper from the European Academy of Allergology and Clinical Immunology. Allergy. 2004;59:690-7.
[21]. Sampson HA, Gerth van Wijk R, Bindslev-Jensen C, Sicherer S, Teuber SS, Burks AW, et al. Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report. J Allergy Clin Immunol. 2012;130:1260-74.
[22]. Bartuzi Z, Kaczmarski M, Czerwionka-Szaflarska M, Małaczynska ´ T, Krogulska A. The diagnosis and management of food allergies. Position paper of the Food Allergy Section the Polish Society of Allergology. Postepy Dermatol Alergol. 2017;34:391-404.
[23]. Erkkola M, Karppinen M, Javanainen J, Räsänen L, Knip M, Virtanen SM. Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women. Am J Epidemiol. 2001;154:466-76.
[24]. Jarosz M. Human nutrition recommendations for Polish population-amendment. Warsaw, Poland: National Food and Nutrition Institute. IZZ; 2012.
[25]. Allan K, Prabhu N, Craig LCA, McNeill G, Kirby B, McLay J, et al. Maternal vitamin D and E intakes during pregnancy are associated with asthma in children. Eur Respir J. 2015;45: 1027-36.
[26]. Maslova E, Hansen S, Strom M, Halldorsson T, Olsen S. Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort. Br J Nutr. 2014;111:1096-108.
[27]. West C, Dunstan J, McCarthy S, Metcalfe J, D’Vaz N, Meldrum S, et al. Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes. Nutrients. 2012;4:1747-58.
[28]. Allen K, Koplin J, Ponsonby A, Gurrin L, Wake M, Vuillermin P, et al. Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol. 2013;131:1109-16.
[29]. Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M. Maternal consumption of dairy products, calcium, and vitamin D during pregnancy and infantile allergic disorders. Ann Allergy Asthma Immunol. 2014;113:82-7.
[30]. Oh SY, Chung J, Kim MK, Kwon SO, Cho BH. Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children. Eur J Clin Nutr. 2010;64:245-52.
[31]. Tan J, McKenzie C, Vuillermin PJ, Goverse G, Vinuesa CG, Mebius RE, et al. Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Rep. 2016;15:2809-24.
[32]. Mcstay CL, Prescott SL, Bower C, Palmer DJ. Maternal folic acid supplementation during pregnancy and childhood allergic disease outcomes: a question of timing? Nutrients. 2017;9:123.
[33]. Gunaratne AW, Makrides M, Collins CT. Maternal prenatal and/or postnatal n−3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. Cochrane Database Syst Rev. 2015;7:CD010085.
[34]. Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, et al. Effect of n−3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. Br Med J. 2012;344:e184.
[35]. Turner PJ, Campbell DE, Boyle RJ, Levin ME. Primary prevention of food allergy: translating evidence from clinical trials to population based recommendations. J Allergy Clin Immunol Pract. 2018;6:367-75.
[36]. Best KP, Sullivan TR, Palmer DJ, Gold M, Martin J, Kennedy D, et al. Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood - a longitudinal analysis of long-term follow-up of a randomized controlled trial. World Allergy Organ J. 2018;11:10.
[37]. Sausenthaler S, Koletzko S, Schaaf B, Lehmann I, Borte M, Herbarth O, et al. Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. Am J Clin Nutr. 2007;85:530-7.
[38]. Alvarez Zallo N, Aguinaga-Ontoso I, Alvarez-Alvarez I, MarinFernandez B, Guillén-Grima F, Azcona-San Julián C. Influence of the Mediterranean diet during pregnancy in the development of wheezing and eczema in infants in Pamplona, Spain. Allergol Immunopathol (Madr). 2017;46:9-14.
[39]. Katz Y, Rajuan N, Goldberg MR, Eisenberg E, Heyman E, Cohen A, et al. Early exposure to cow’s milk protein is protective against IgE-mediated cow’s milk protein allergy. Allergy Clin Immunol. 2010;126:77-82.
[40].Tuokkola J, Luukkainen P, Tapanainen H, Kaila M, Vaarala O, Kenward MG, et al. Maternal diet during pregnancy and lactation and cow’s milk allergy in offspring. Eur J Clin Nutr. 2016;70:554-9.
[41]. Järvinen KM, Westfall J, De Jesus M, Mantis NJ, Carroll JA, Metzger DW, et al. Role of maternal dietary peanut exposure in development of food allergy and oral tolerance. PLoS One. 2015;10:e0143855.
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Dec 15, 2019
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Ku´smierek, M., Sardecka, I., Ło´s-Rycharska, E., & Krogulska, A. (2019). The impact of immunomodulatory factors from maternal diet during pregnancy on cow’s milk allergy in offspring - A pilot study in the paediatric population of the Kuyavian-Pomeranian Voivodship. Allergologia Et Immunopathologia, 47(6), 570-578. https://all-imm.com/index.php/aei/article/view/275
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How to Cite
Ku´smierek, M., Sardecka, I., Ło´s-Rycharska, E., & Krogulska, A. (2019). The impact of immunomodulatory factors from maternal diet during pregnancy on cow’s milk allergy in offspring - A pilot study in the paediatric population of the Kuyavian-Pomeranian Voivodship. Allergologia Et Immunopathologia, 47(6), 570-578. https://all-imm.com/index.php/aei/article/view/275