IL-33 is associated with allergy in children sensitized to the cat
Main Article Content
Keywords
Children, Asthma, IL-33, Cat sensitization, Pets keeping, Allergic rhinitis, Pregnancy
Abstract
Background: Several studies suggest that early-life exposure to animal allergens constitutes a relevant risk factor for the development of allergic sensitization.
Objectives: The aim of the present study was to determine the role of interleukin-33 in children sensitive to cat allergen with allergic rhinitis and/or asthma.
Methods: The study included 51 children aged 5---18 years, both sexes, allergic to cats. Sensitization to cat allergen was confirmed by skin prick tests or specific IgE. Children were evaluated for the presence of bronchial asthma, atopic dermatitis, allergic rhinitis. A questionnaire evaluating the occurrence of allergic symptoms in children after contact with the cat and dog was performed. Mothers completed a questionnaire regarding cat exposure: during pregnancy and having a cat at home. A blood sample was taken from all children to measure the level of IL-33 in the serum.
Results: Keeping a cat in the home, once in the past, or having a cat in the home during the mother’s pregnancy, revealed a statistically significant relationship with IL-33 levels in the studied patients. Also, daily contact with a cat during pregnancy affected the level of IL-33. Higher levels of IL-33 were shown in people with hypersensitivity to cat and pollen allergens and cat and other animals. In patients with bronchial asthma higher levels of IL-33 were found than in patients without bronchial asthma.
Conclusions: Increased serum levels of IL-33 is related with keeping cats during pregnancy and in early childhood and can be associated with the development of asthma in children.
References
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16. Li Y, Wang W, Lv Z, Li Y, Chen Y, Huang K, et al. Elevated expression of IL-33 and TSLP in the airways of human asthmatics in vivo: a potential biomarker of severe refractory disease. J Immunol. 2018;200:2253-62.
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22. Gasiuniene E, Janulaityte I, Zemeckiene Z, Barkauskiene D, Sitkauskiene B. Elevated levels of interleukin-33 are associated with allergic and eosinophilic asthma. Scand J Immunol. 2018;(October):e12724.
23. Ravanetti L, Dijkhuis A, Dekker T, Sabogal Pineros YS, Ravi A, Dierdorp BS, et al. IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity. J Allergy Clin Immunol. 2018;(October), pii: S0091-6749(18)31434-9.
24. Zoltowska AM, Lei Y, Fuchs B, Rask C, Adner M, Nilsson GP. The interleukin-33 receptor ST2 is important for the development of peripheral airway hyperresponsiveness and inflammation in a house dust mite mouse model of asthma. Clin Exp Allergy. 2016;46(March (3)):479-90.
25. Hesselmar B, Hicke-Roberts A, Lundell AC, Adlerberth I, Rudin A, Saalman R, et al. Pet-keeping in early life reduces the risk of allergy in a dose-dependent fashion. PLoS One. 2018;13(December (12)):e0208472.
26. Shugang L, Yuexia S, Jing H, Kong X, Wang P, Zhang Q, et al. Pet keeping in childhood and asthma and allergy among children in Tianjin area, China. PLoS One. 2018;13(5):e0197274.
27. Lombardi E, Simoni M, La Grutta S, Viegi G, Bisanti L, Chellini E, et al. Effects of pet exposure in the first year of life on respiratory and allergic symptoms in 7-yr-old children. The SIDRIA-2 study. Pediatr Allergy Immunol. 2010;21 March (2 Pt 1):268-76.
28. Lodge CJ, Lowe AJ, Gurrin LC, Matheson MC, Balloch A, Axelrad C, et al. Pets at birth do not increase allergic disease in at-risk children. Clin Exp Allergy. 2012;42(September (9)):1377-85.
29. Brunekreef B, Von Mutius E, Wong G, Odhiambo J, García-Marcos L, Foliaki S, et al. Exposure to cats and dogs, and symptoms of asthma, rhinoconjunctivitis, and eczema. Epidemiology. 2012;23(September (5)):742-50.
30. Collin SM, Granell R, Westgarth C, Murray J, Paul E, Sterne JA, et al. Pet ownership is associated with increased risk of non-atopic asthma and reduced risk of atopy in childhood: findings from a UK birth cohort. Clin Exp Allergy. 2015;45(January (1)):200-10.
31. Cevikbas F, Steinhoff MJ. IL-33: a novel danger signal system in atopic dermatitis. Investig Dermatol. 2012;132:1326-9.
32. Du HY, Fu HY, Li DN, Qiao Y, Wang QW, Liu WJ. The expression and regulation of interleukin-33 in human epidermal keratinocytes: a new mediator of atopic dermatitis and its possible signaling pathway. Interferon Cytokine Res. 2016;36:552-62.
33. Alase A, Seltmann J, Werfel T, Wittmann M. Interleukin-33 modulates the expression of human -defensin 2 in human primary keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis. Br J Dermatol. 2012;167:1386-9.
34. Savinko T, Matikainen S, Saarialho-Kere U, Lehto M, Wang G, Lehtimäki S, et al. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Investig Dermatol. 2012;132:1392-400.
35. Seltmann J, Roesner LM, von Hesler FW, Wittmann M, Werfel T. IL-33 impacts on the skin barrier by downregulating the expression of filaggrin. Allergy Clin Immunol. 2015;135:1659-61.
36. Nygaard U, Hvid M, Johansen C, Buchner M, Fölster-Holst R, Deleuran M, et al. TSLP, IL-31, IL-33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis. J Eur Acad Dermatol Venereol. 2016;30(November (11)):1930-8.
37. Savinko T, Matikainen S, Saarialho-Kere U, Lehto M, Wang G, Lehtimäki S, et al. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol. 2012;132(5):1392-400.
38. Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, et al. Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. Mucosal Immunol. 2017;10(November (6)): 1491-503.
39. Saluja R, Khan M, Church MK, Maurer M. The role of IL-33 and mast cells in allergy and inflammation. Clin Transl Allergy. 2015;5:33.
40. Imai Y, Yasuda K, Sakaguchi Y, Haneda T, Mizutani H, Yoshimoto T, et al. Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. Proc Natl Acad Sci USA. 2013;110(34):13921-6.
41. Glück J, Rymarczyk B, Rogala B. Serum IL-33 but not ST2 level is elevated in intermittent allergic rhinitis and is a marker of the disease severity. Inflamm Res. 2012;61:547-50.
42. Asaka D, Yoshikawa M, Nakayama T, Yoshimura T, Moriyama H, Otori N. Elevated levels of interleukin-33 in the nasal secretions of patients with allergic rhinitis. Int Arch Allergy Immunol. 2012;158 Suppl. 1:47-50.
43. Akasaki S, Matsushita K, Kato Y, Fukuoka A, Iwasaki N, Nakahira M, et al. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. Int Immunol. 2016;28:65-76.
2. Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, et al. Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios. Microbiome. 2017;5(April (1)):40.
3. Liccardi G, Triggiani M, Piccolo A, Salzillo A, Parente R, Manzi F, et al. Sensitization to common and uncommon pets or other furry animals: which may be common mechanisms? Transl Med UniSa. 2016;14(May):9-14.
4. TNS Polska, pa´zdziernik 2014, www.tnsglobal.pl.
5. Scadding GW, Eifan A, Penagos M, Dumitru A, Switzer A, McMahon O, et al. Local and systemic effects of cat allergen nasal provocation. Clin Exp Allergy. 2015;45(March (3)):613-23.
6. Takatori H, Makita S, Ito T, Matsuki A, Nakajima H. Regulatory mechanisms of IL-33-ST2-mediated allergic inflammation. Front Immunol. 2018;9(September):2004.
7. Ding W, Zou GL, Zhang W, Lai XN, Chen HW, Xiong LX. Interleukin-33: its emerging role in allergic diseases. Molecules.
2018;23(July (7)).
8. Rui Z, Dan W, Kai W, Gao WX, Yang QT, Jiang LJ, et al. Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps. Clin Transl Allergy. 2018;8:50. Published online 29 November 2018.
9. Soyka MB, Holzmann D, Basinski TM, Wawrzyniak M, Bannert C, Bürgler S, et al. The induction of IL-33 in the sinus epithelium and its influence on T-helper cell responses. PLoS One. 2015;10:e0123163.
10. Liao B, Cao PP, Zeng M, Wawrzyniak M, Bannert C, Bürgler S, et al. Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps. Allergy. 2015;70:1169-80.
11. Ozturan A, Eyigor H, Eyigor M, Osma U, Yilmaz MD, Selcuk OT, et al. The role of IL-25 and IL-33 in chronic rhinosinusitis with or without nasal polyps. Eur Arch Otorhinolaryngol. 2017;274:283-8.
12. Becker AB, Abrams EM. Asthma guidelines: the Global Initiative for Asthma in relation to national guidelines. Curr Opin Allergy Clin Immunol. 2017;17(April (2)):99-103.
13. Eichenfield LF, Hanifin JM, Luger TA, Stevens SR, Pride HB. Consensus conference on pediatric atopic dermatitis. J Am Acad Dermatol. 2003;49(6):1088-95.
14. Bousquet J, Schünemann HJ, Samolinski B, Demoly P, BaenaCagnani CE, Bachert C, et al. World Health Organization Collaborating Center for Asthma and Rhinitis. Allergic Rhinitis and its impact on asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol. 2012;130: 1049-62.
15. Bianchetti L, Marini MA, Isgrò M, Bellini A, Schmidt M, Mattoli S. IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma. Biochem Biophys Res Commun. 2012;426:116-21.
16. Li Y, Wang W, Lv Z, Li Y, Chen Y, Huang K, et al. Elevated expression of IL-33 and TSLP in the airways of human asthmatics in vivo: a potential biomarker of severe refractory disease. J Immunol. 2018;200:2253-62.
17. Queiroz GA, Costa RS, Alcantara-Neves NM, Nunes de Oliveira Costa G, Barreto ML, Carneiro VL, et al. IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. Int J Immunogenet. 2017;44(April (2)):51-61.
18. Préfontaine D, Nadigel J, Chouiali F, Audusseau S, Semlali A, Chakir J, et al. Increased IL-33 expression by epithelial cells in bronchial asthma. J Allergy Clin Immunol. 2010;125:752-4.
19. Wisniewski JA, Muehling LM, Eccles JD, Capaldo BJ, Agrawal R, Shirley DA, et al. TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status. J Allergy Clin Immunol. 2018;141(June (6)):2048-60.e13.
20. Momen T, Ahanchian H, Reisi M, Shamsdin SA, Shahsanai A, Keivanfar M. Comparison of interleukin-33 serum levels in asthmatic patients with a control group and relation with the severity of the disease. Int J Prev Med. 2017;8(August):65.
21. Poulsen NN, Bjerregaard A, Khoo SK, Laing IA, Le Souëf P, Backer V, et al. Airway interleukin-33 and type 2 cytokines in adult patients with acute asthma. Respir Med. 2018;140(July):50-6.
22. Gasiuniene E, Janulaityte I, Zemeckiene Z, Barkauskiene D, Sitkauskiene B. Elevated levels of interleukin-33 are associated with allergic and eosinophilic asthma. Scand J Immunol. 2018;(October):e12724.
23. Ravanetti L, Dijkhuis A, Dekker T, Sabogal Pineros YS, Ravi A, Dierdorp BS, et al. IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity. J Allergy Clin Immunol. 2018;(October), pii: S0091-6749(18)31434-9.
24. Zoltowska AM, Lei Y, Fuchs B, Rask C, Adner M, Nilsson GP. The interleukin-33 receptor ST2 is important for the development of peripheral airway hyperresponsiveness and inflammation in a house dust mite mouse model of asthma. Clin Exp Allergy. 2016;46(March (3)):479-90.
25. Hesselmar B, Hicke-Roberts A, Lundell AC, Adlerberth I, Rudin A, Saalman R, et al. Pet-keeping in early life reduces the risk of allergy in a dose-dependent fashion. PLoS One. 2018;13(December (12)):e0208472.
26. Shugang L, Yuexia S, Jing H, Kong X, Wang P, Zhang Q, et al. Pet keeping in childhood and asthma and allergy among children in Tianjin area, China. PLoS One. 2018;13(5):e0197274.
27. Lombardi E, Simoni M, La Grutta S, Viegi G, Bisanti L, Chellini E, et al. Effects of pet exposure in the first year of life on respiratory and allergic symptoms in 7-yr-old children. The SIDRIA-2 study. Pediatr Allergy Immunol. 2010;21 March (2 Pt 1):268-76.
28. Lodge CJ, Lowe AJ, Gurrin LC, Matheson MC, Balloch A, Axelrad C, et al. Pets at birth do not increase allergic disease in at-risk children. Clin Exp Allergy. 2012;42(September (9)):1377-85.
29. Brunekreef B, Von Mutius E, Wong G, Odhiambo J, García-Marcos L, Foliaki S, et al. Exposure to cats and dogs, and symptoms of asthma, rhinoconjunctivitis, and eczema. Epidemiology. 2012;23(September (5)):742-50.
30. Collin SM, Granell R, Westgarth C, Murray J, Paul E, Sterne JA, et al. Pet ownership is associated with increased risk of non-atopic asthma and reduced risk of atopy in childhood: findings from a UK birth cohort. Clin Exp Allergy. 2015;45(January (1)):200-10.
31. Cevikbas F, Steinhoff MJ. IL-33: a novel danger signal system in atopic dermatitis. Investig Dermatol. 2012;132:1326-9.
32. Du HY, Fu HY, Li DN, Qiao Y, Wang QW, Liu WJ. The expression and regulation of interleukin-33 in human epidermal keratinocytes: a new mediator of atopic dermatitis and its possible signaling pathway. Interferon Cytokine Res. 2016;36:552-62.
33. Alase A, Seltmann J, Werfel T, Wittmann M. Interleukin-33 modulates the expression of human -defensin 2 in human primary keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis. Br J Dermatol. 2012;167:1386-9.
34. Savinko T, Matikainen S, Saarialho-Kere U, Lehto M, Wang G, Lehtimäki S, et al. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Investig Dermatol. 2012;132:1392-400.
35. Seltmann J, Roesner LM, von Hesler FW, Wittmann M, Werfel T. IL-33 impacts on the skin barrier by downregulating the expression of filaggrin. Allergy Clin Immunol. 2015;135:1659-61.
36. Nygaard U, Hvid M, Johansen C, Buchner M, Fölster-Holst R, Deleuran M, et al. TSLP, IL-31, IL-33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis. J Eur Acad Dermatol Venereol. 2016;30(November (11)):1930-8.
37. Savinko T, Matikainen S, Saarialho-Kere U, Lehto M, Wang G, Lehtimäki S, et al. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol. 2012;132(5):1392-400.
38. Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, et al. Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. Mucosal Immunol. 2017;10(November (6)): 1491-503.
39. Saluja R, Khan M, Church MK, Maurer M. The role of IL-33 and mast cells in allergy and inflammation. Clin Transl Allergy. 2015;5:33.
40. Imai Y, Yasuda K, Sakaguchi Y, Haneda T, Mizutani H, Yoshimoto T, et al. Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. Proc Natl Acad Sci USA. 2013;110(34):13921-6.
41. Glück J, Rymarczyk B, Rogala B. Serum IL-33 but not ST2 level is elevated in intermittent allergic rhinitis and is a marker of the disease severity. Inflamm Res. 2012;61:547-50.
42. Asaka D, Yoshikawa M, Nakayama T, Yoshimura T, Moriyama H, Otori N. Elevated levels of interleukin-33 in the nasal secretions of patients with allergic rhinitis. Int Arch Allergy Immunol. 2012;158 Suppl. 1:47-50.
43. Akasaki S, Matsushita K, Kato Y, Fukuoka A, Iwasaki N, Nakahira M, et al. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. Int Immunol. 2016;28:65-76.
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Mar 15, 2020
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Smejda, K., Borkowska, A., Jerzynska, J., Brzozowska, A., Stelmach, W., & Stelmach, I. (2020). IL-33 is associated with allergy in children sensitized to the cat. Allergologia Et Immunopathologia, 48(2), 130-136. https://all-imm.com/index.php/aei/article/view/228
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How to Cite
Smejda, K., Borkowska, A., Jerzynska, J., Brzozowska, A., Stelmach, W., & Stelmach, I. (2020). IL-33 is associated with allergy in children sensitized to the cat. Allergologia Et Immunopathologia, 48(2), 130-136. https://all-imm.com/index.php/aei/article/view/228