Interleukin 10: the critical role of a pleiotropic cytokine in food allergy
Main Article Content
Keywords
Food allergy, IL-10, IL-10 gene polymorphisms, Tregs, Dedritic cells
Abstract
Despite advances in research, the pathophysiology of food allergy has not yet been fully elucidated. IL-10 has both a pro-and anti-inflammatory effect on the development of food allergy and in order to understand its different immune-modulatory effects the factors that influence the inflammatory microenvironment need to be taken into account. Specific single nucleotide polymorphisms of the IL-10 gene seem to confer an increased risk of developing food allergy, but to date there is a substantial lack of genome-wide association studies regarding the genetic and epigenetic underpinnings of the disease. Special interest has been drawn to the development of allergen-specific regulatory CD4+CD25+ T-cells secreting IL-10 in the immunotherapy of allergic diseases. In addition, a distinct population of human tolerogenic dendritic cells (DC), DC-10 seems to hold great potential and could potentially serve as a therapeutic tool to improve the management of food allergy.
References
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[13]. Pelz BJ, Bryce PJ. Pathophysiology of Food Allergy. Pediatr Clin North Am. 2015;62(6):1363-75, http://dx.doi.org/10.1016/j.pcl.2015.07.004.
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[15]. Tordesillas L, Berin MC. Mechanisms of Oral Tolerance. Clin Rev Allergy Immunol. 2018;55(2):107-17, http://dx.doi.org/10.1007/s12016-018-8680-5.
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Nedelkopoulou, N., Dhawan, A., Xinias, I., Gidaris, D., & Farmaki, E. (2020). Interleukin 10: the critical role of a pleiotropic cytokine in food allergy. Allergologia Et Immunopathologia, 48(4), 401-408. https://all-imm.com/index.php/aei/article/view/168
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How to Cite
Nedelkopoulou, N., Dhawan, A., Xinias, I., Gidaris, D., & Farmaki, E. (2020). Interleukin 10: the critical role of a pleiotropic cytokine in food allergy. Allergologia Et Immunopathologia, 48(4), 401-408. https://all-imm.com/index.php/aei/article/view/168