Changing trends in aeroallergen sensitization Evidence for gender-specific profiles
Main Article Content
Keywords
allergic diseases, aeroallergens
Abstract
Background: Sex-related differences in allergic diseases are recognized; however, variation in aeroallergen sensitization patterns across clinical populations remains incompletely characterized.
Objective: To examine sex-specific differences in sensitization profiles and polysensitization across two independent clinical cohorts.
Methods: Skin prick test (SPT) results and serum total IgE levels from 226 participants were retrospectively analyzed from two cross-sectional cohorts (2005–2006 and 2011–2012) at a tertiary referral center. Sensitization patterns and polysensitization were compared by sex and diagnosis. Multivariable logistic regression models were used to assess independent associations, adjusting for age, diagnosis, and cohort.
Results: In the earlier cohort, females exhibited higher total IgE levels and a greater prevalence of allergic rhinitis, whereas asthma predominated among males. In the later cohort, males demonstrated broader sensitization profiles and higher polysensitization rates. After adjustment for age and diagnosis, sex remained independently associated with polysensitization (aOR 0.41, 95% CI 0.17–0.99, p=0.048), while cohort differences were not statistically significant. House dust mites were the most prevalent allergen in both cohorts.
Conclusions: Sex significantly influences aeroallergen sensitization patterns in clinical populations. The observed cohort differences appear to be largely explained by demographic and diagnostic composition rather than definitive temporal trends.
References
2. González-Pérez R, Galván-Calle CA, Galán T, Poza-Guedes P, Sánchez-Machín I, Enrique-Calderón OM, et al. Molecular Signatures of Aeroallergen Sensitization in Respiratory Allergy: A Comparative Study Across Climate-Matched Populations. Int J Mol Sci. 2024 Dec;26(1):284. https://doi. org/10.3390/ijms26010284
3. Ajana R, Rachoń D, Gałęzowska G. Reproductive toxicity of per- and polyfluoroalkyl substances. Environ Toxicol Pharmacol. 2025 Aug;117:104740. https://doi.org/10.1016/j. etap.2025.104740
4. Nadaf AA, Pranavi C, Abhinaya D, Dholi SK. Retrospective cohort study: a gender-based analysis of symptom severity and age correlation in nasal septum deviation. World J Biol Pharm Health Sci. 2025 Jan;21(1):422–26. https://doi. org/10.30574/wjbphs.2025.21.1.1035
5. Ying X, Qi X, Yin Y, Wang H, Zhang H, Jiang H, et al. Allergen sensitization among children with allergic diseases in Shanghai, China: age and sex differences. Respir Res. 2022 Apr;23(1):95. https://doi.org/10.1186/s12931-022-02008-7
6. Yim Y, Jo H, Park S, et al. Sex-specific and long-term trends of asthma, allergic rhinitis, and atopic dermatitis in South Korea, 2007–2022: a nationwide representative study. Int Arch Allergy Immunol. 2025 Sep;186(2):166–83. https://doi. org/10.1159/000540928
7. Pinart M, Keller T, Reich A, Fröhlich M, Cabieses B, Hohmann C, et al. Sex-related allergic rhinitis prevalence switch from childhood to adulthood: a systematic review and meta-analysis. Int Arch Allergy Immunol. 2017 Apr;172(4):224– 35. https://doi.org/10.1159/000464324
8. Fröhlich M, Pinart M, Keller T, Reich A, Cabieses B, Hohmann C, et al. Is there a sex shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis. Clin Transl Allergy. 2017 Dec;7:44. https://doi.org/10.1186/s13601-017-0176-5
9. Dai L, Liu J, Zhao Q, Li M, Zhou Y, Chen Z, et al. Investigation of allergic sensitizations in children with allergic rhinitis and/ or asthma. Front Pediatr. 2022 Mar;10:84229. https://doi. org/10.3389/fped.2022.842293
10. Pothirat C, Chaiwong W. Aeroallergen sensitization and clinical characteristics of subjects with chronic rhinitis in Chiang Mai, Thailand: a twenty-year retrospective study. J Asthma Allergy. 2021 Jul;14:789–95. https://doi.org/10.2147/JAA. S315081
11. Craig TJ. Aeroallergen sensitization in asthma: prevalence and correlation with severity. Allergy Asthma Proc. 2010 Mar– Apr;31(2):96–102. https://doi.org/10.2500/aap.2010.31.3310
12. Kothandarama K, Mohindra S, Arungovind K, Mahendru S. Prevalence of common aeroallergens in allergic rhinitis and its correlation with bronchial asthma: a study on 798 patients by skin prick test. Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):1651–59. https://doi.org/10.1007/ s12070-023-03643-2
13. Trinh TH, Nguyen PT, Tran TT, Pawankar R, Pham DL. Profile of aeroallergen sensitizations in allergic patients living in southern Vietnam. Front Allergy. 2023 Jan;3:1058865. https://doi.org/10.3389/falgy.2022.1058865
14. Ochoa-Avilés C, Morillo D, Rodriguez A, Cooper PJ, Andrade S, Molina M, et al. Prevalence and risk factors for asthma, rhi-nitis, eczema, and atopy among preschool children in an Andean city. PLoS One. 2020;15(7):e0236843. https://doi. org/10.1371/journal.pone.0236843
15. Lake IR, Jones NR, Agnew M, Goodess CM, Giorgi F, Hamaoui-Laguel L, et al. Climate change and future pollen allergy in Europe. Environ Health Perspect. 2016 Aug;125(3):385–91. https://doi.org/10.1289/EHP173
16. Ziska LH, Makra L, Harry SK, Bruffaerts N, Hendrickx M, Coates F, Saarto A, et al. Temperature-related changes in airborne allergenic pollen abundance and seasonality across the northern hemisphere: a retrospective data analysis. Lancet Planet Health. 2019 Mar;3(3):e124–e131. https://doi. org/10.1016/S2542-5196(19)30015-4
17. Bousquet J, Sousa-Pinto B, Vieira RJ, Schünemann HJ, Zuberbier T, Bognanni A, et al. Methodology for the development of the allergic rhinitis and its impact on asthma (ARIA)-EAACI 2024-2025 Guidelines: From evidence-to-decision frameworks to digitalized shared decision-making algorithms. Allergy. 2026 Feb;81(2):427–453. https://doi. org/10.1111/all.70100. Epub 2025 Nov 21. PMID: 41268627; PMCID: PMC12862529.
18. Chan-Yeung M, Manfreda J, Dimich-Ward H, Lam J, Ferguson A, Warren P, et al. Mite and cat allergen levels in homes and severity of asthma. Am J Respir Crit Care Med. 1995 Dec;152 (6 Pt 1):1805–11. https://doi.org/10.1164/ajrccm.152.6.8520740
19. Custovic A, Taggart SC, Francis HC, Chapman MD, Woodcock A. Exposure to house dust mite allergens and the clinical activity of asthma. J Allergy Clin Immunol. 1996 Jul;98(1):64–72. https://doi.org/10.1016/S0091-6749(96)70227-0
20. van der Heide S, De Monchy JG, De Vries K, Dubois AE, Kauffman HF. Seasonal differences in airway hyperresponsiveness in asthmatic patients: relationship with allergen exposure and sensitization to house dust mites. Clin Exp Allergy. 1997 Jun;27(6):627–33. https://doi. org/10.1111/j.1365-2222.1997.tb01189.x
21. Tizek L, Redlinger E, Ring J, Eyerich K, Biedermann T, Zink A. Urban vs rural: prevalence of self-reported allergies in various occupational and regional settings. World Allergy Organ J. 2022 Jan;15(1):100625. https://doi.org/10.1016/j. waojou.2022.100625
22. Mehulić M, Mehulić K, Vuljanko IM, Kukulj S, Grle SP, Vukić AD, et al. Changing pattern of sensitization in Croatia to aeroallergens in adult population referring to an allergy clinic during a period of 15 years. Coll Antropol. 2011 Jun;35(2):529–36.
23. Lou H, Ma S, Zhao Y, Cao F, He F, Liu Z, et al. Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China. Sci Rep. 2017 Aug;7:9286. https://doi.org/10.1038/s41598-017-10111-9
24. Zhao Z, Chen L, Huang, C, Huang Zh, Liu X, Hu B, et al. Allergen sensitization patterns in children with allergic rhinitis: insights from a four-year retrospective study in Shenzhen, China. BMC Pediatr. 2025;25: 544. https://doi.org/10.1186/ s12887-025-05885-1
25. Mkilima T. Urban aerosols, the microbiome, and the rise of “urban atopy”. Aerosol Sci Eng. 2025 Jun. https://doi. org/10.1007/s41810-025-00331-2
26. Nieman DC, Wentz LM. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019 May;8(3):201–17. https://doi.org/10.1016/j. jshs.2018.09.009