Seasonal allergic rhinitis and the role of apitherapy

Main Article Content

Karsten Münstedt
Heidrun Männle

Keywords

Allergic rhinitis, Hay fever, Honey, Pollen, Royal jelly, Apitherapy

Abstract

Background: Apitherapy represents a certain form of complementary and alternative medicine that uses bee products in combination with other methods from this field. One of the basic concepts of this type of medicine is that all diseases can be treated using apitherapy. This study was performed to assess the recommendations from authors of books on apitherapy regarding the treatment of seasonal allergic rhinitis and compare them to findings from the scientific literature.


Methods: One hundred and twenty-nine books on apitherapy were analysed regarding recommendations for allergic seasonal rhinitis. Scientific evidence regarding the efficacy of using various bee products was searched via PubMed and JUST find.


Results: Only 38.8% of the apitherapy books mentioned seasonal allergic rhinitis. Among these books, we found 29 different recommendations in favour of bee products and one against the use of honey. The most reasonable recommendation according to clinical studies on the subject, namely the use of a mix of honey and pollen, was only found once (0.8%).


Conclusions: The large discrepancies and number of different recommendations demonstrate that apitherapy is not a consistent type of medicine. The recommendations regarding seasonal allergic rhinitis in the vast majority of apitherapy books cannot be considered adequate when compared to the scientific findings.

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References

1. Mims JW. Epidemiology of allergic rhinitis. Int Forum Allergy Rhinol. 2014;4 Suppl. 2:S18-20, http://dx.doi.org/10.1002/alr.21385.

2. Blaiss MS, Hammerby E, Robinson S, Kennedy-Martin T, Buchs S. The burden of allergic rhinitis and allergic rhinoconjunctivitis on adolescents: a literature review. Ann Allergy Asthma Immunol. 2018;121, http://dx.doi.org/10.1016/j.anai.2018.03.028, 43-52.e3.

3. Romano MR, James S, Farrington E, Perry R, Elliott L. The impact of perennial allergic rhinitis with/without allergic asthma on sleep, work and activity level. Allergy Asthma Clin Immunol. 2019;15:81, http://dx.doi.org/10.1186/s13223-019-0391-9.

4. Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, et al. Clinical practice guideline: allergic rhinitis. Otolaryngol Head Neck Surg. 2015;152 Suppl., http://dx.doi.org/10.1177/0194599814561600. S1-43.

5. Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, et al. Japanese guidelines for allergic rhinitis 2017. Allergol Int. 2017;66:205-19, http://dx.doi.org/10.1016/j.alit.2016.11.001.

6. Hauk L. Treatment of seasonal allergic rhinitis: a guideline from the AAAAI/ACAAI Joint Task Force on Practice Parameters. Am Fam Physician. 2018;97:756-7.

7. Roger A, Quilez E, Depreux N, Farre M. DIRAE study: seasonal allergic rhinitis distribution in Spain. Allergol Immunopathol (Madr). 2013;41:151-7, http://dx.doi.org/10.1016/j.aller.2012.03.005.

8. Dhami S, Nurmatov U, Arasi S, Khan T, Asaria M, Zaman H, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis. Allergy. 2017;72:1597-631, http://dx.doi.org/10.1111/all.13201.

9. Kern J, Bielory L. Complementary and alternative therapy (CAM) in the treatment of allergic rhinitis. Curr Allergy Asthma Rep. 2014;14:479, http://dx.doi.org/10.1007/s11882-014-0479-8.

10. Kłak A, Raciborski F, Krzych-Fałta E, Opoczynska- ´ ´Swie˙zewska D, Szymanski ´ J, Lipiec A, et al. Persons with allergy symptoms use alternative medicine more often. Pneumonol Alergol Pol. 2016;84:251-7, http://dx.doi.org/10.5603/PiAP.2016.0031.

11. Ipci K, Oktemer T, Muluk NB, S¸ahin E, Altıntoprak N, Bafaqeeh SA, et al. Alternative products to treat allergic rhinitis and alternative routes for allergy immunotherapy. Am J Rhinol Allergy. 2016;30:8-10, http://dx.doi.org/10.2500/ajra.2016.30.4364.

12. Bonizzoni G, Caminati M, Ridolo E, Landi M, Ventura MT, Lombardi C, et al. Use of complementary medicine among patients with allergic rhinitis: an Italian nationwide survey. Clin Mol Allergy. 2019;17:2, http://dx.doi.org/10.1186/s12948-019-0107-1.

13. Yonekura S, Okamoto Y, Sakurai D, Sakurai T, Iinuma T, Yamamoto H, et al. Complementary and alternative medicine for allergic rhinitis in Japan. Allergol Int. 2017;66:425-31.

14. Feng S, Han M, Fan Y, Yang G, Liao Z, Liao W, et al. Acupuncture for the treatment of allergic rhinitis: a systematic review and meta analysis. Am J Rhinol Allergy. 2015;29:57-62, http://dx.doi.org/10.2500/ajra.2015.29.4116.

15. Cho HK, Jeong YM, Lee HS, Lee YJ, Hwang SH. Efficacy of endonasal phototherapy for relieving the symptoms of allergic rhinitis: meta-analysis. Am J Rhinol Allergy. 2015;29:283-91, http://dx.doi.org/10.2500/ajra.2015.29.4190.

16. Banerjee K, Mathie RT, Costelloe C, Howick J. Homeopathy for allergic rhinitis: a systematic review. J Altern Complement Med. 2017;23:426-44, http://dx.doi.org/10.1089/acm.2016.0310.

17. Nolte H, Maloney J. The global development and clinical efficacy of sublingual tablet immunotherapy for allergic diseases. Allergol Int. 2018;67:301-8, http://dx.doi.org/10.1016/j.alit.2018.03.008.

18. Popescu FD. Cross-reactivity between aeroallergens and food allergens. World J Methodol. 2015;5:31-50, http://dx.doi.org/10.5662/wjm.v5.i2.31.

19. Pitsios C, Chliva C, Mikos N, Kompoti E, Nowak-Wegrzyn A, Kontou-Fili K. Bee pollen sensitivity in airborne pollen allergic individuals. Ann Allergy Asthma Immunol. 2006;97:703-6.

20. Arbuckle J. Severe allergic rhinitis, perennial sinusitis and antihistamine dependence resolved with naturopathic treatment: a case study and short literature review (review). Aust J Herbal Med. 2017;29:142-9.

21. von Arx K. Resultate verschiedener Behandlungsmethoden bei Pollenallergie unter spezieller Berücksichtigung der peroralen Desensibilisierung pollenallergischer Kinder mit Honig [Resultant therapeutic method variations in pollen allergy with special consideration of oral desensitizing of pollen allergic children with honey]. Praxis. 1957;46:717-21.

22. Croft L. Honey and health. Wellingborough, Great Britain: Thorsons Publishing Group; 1987.

23. Rajan TV, Tennen H, Lindquist RL, Cohen L, Clive J. Effect of ingestion of honey on symptoms of rhinoconjunctivitis. Ann Allergy Asthma Immunol. 2002;88:198-203.

24. Münstedt K, Kalder M. Honey as a treatment option for rhinoconjunctivitis. J ApiProduct ApiMedical Sci. 2010;4:145-8.

25. Asha’ari ZA, Ahmad MZ, Jihan WS, Che CM, Leman I. Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East coast of Peninsular Malaysia. Ann Saudi Med. 2013;33:469-75, http://dx.doi.org/10.5144/0256-4947.2013.469.

26. Salehi A, Jabarzare S, Neurmohamadi M, Kheiri S, Rafieian-Kopaei M. A double-blind clinical trial on the efficacy of honey drop in vernal keratoconjunctivitis. Evid Based Complement Alternat Med. 2014:287540, http://dx.doi.org/10.1155/2014/287540.

27. Wortmann F. Perorale Desensibilisierung bei Kindern [Oral desensitization in children]. Allerg Asthma (Leipz). 1965;11:118-23.

28. Saarinen K, Jantunen J, Haahtela T. Birch pollen honey for birch pollen allergy - a randomized controlled pilot study. Int Arch Allergy Immunol. 2011;155:160-6, http://dx.doi.org/10.1159/000319821.

29. Yasar M, Savranlar Y, Karaman H, Sagit M, Silici S, Ozcan I. Effects of propolis in an experimental rat model of allergic rhinitis. Am J Otolaryngol. 2016;37:287-93, http://dx.doi.org/10.1016/j.amjoto.2016.03.007.

30. Tani H, Hasumi K, Tatefuji T, Hashimoto K, Koshino H, Takahashi S. Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes. Bioorg Med Chem. 2010;18:151-7, http://dx.doi.org/10.1016/j.bmc.2009.11.007.

31. Shinmei Y, Yano H, Kagawa Y, Izawa K, Akagi M, Inoue T, et al. Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. Immunopharmacol Immunotoxicol. 2009;31:688-93, http://dx.doi.org/10.3109/08923970903078443.

32. Shaha A, Mizuguchi H, Kitamura Y, Fujino H, Yabumoto M, Takeda N, et al. Effect of royal jelly and Brazilian green propolis on the signaling for histamine H(1) receptor and interleukin-9 gene expressions responsible for the pathogenesis of the allergic rhinitis. Biol Pharm Bull. 2018;41:1440-7, http://dx.doi.org/10.1248/bpb.b18-00325.

33. Shin SH, Ye MK, Choi SY, Park KK. Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model. Mol Med Rep. 2018;17:6632-8, http://dx.doi.org/10.3892/mmr.2018.8720.

34. Shin SH, Kim YH, Kim JK, Park KK. Anti-allergic effect of bee venom in an allergic rhinitis mouse model. Biol Pharm Bull. 2014;37:1295-300.

35. Fotin AV, Gel’medova NN. Treatment of allergic rhinosinusitis in children with bee venom. Vestn Otorinolaringol. 1981:42-4.

36. Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLOS ONE. 2015;10:e0126971, http://dx.doi.org/10.1371/journal.pone.0126971.

37. Takahama H, Shimazu T. Food-induced anaphylaxis caused by ingestion of royal jelly. J Dermatol. 2006;33:424-6.

38. de Groot AC. Propolis: a review of properties, applications, chemical composition, contact allergy, and other adverse effects. Dermatitis. 2013;24:263-82, http://dx.doi.org/10.1097/DER.0000000000000011.

39. Kiistala R, Hannuksela M, Mäkinen-Kiljunen S, Niinimäki A, Haahtela T. Honey allergy is rare in patients sensitive to pollens. Allergy. 1995;50:844-7.

40. Choi JH, Jang YS, Oh JW, Kim CH, Hyun IG. Bee pollen-induced anaphylaxis: a case report and literature review. Allergy Asthma Immunol Res. 2015;7:513-7, http://dx.doi.org/10.4168/aair.2015.7.5.513.