Nasal allergen challenge with Blomia tropicalis in children and adolescents
Main Article Content
Keywords
rhinitis, aeroallergens, diagnosis, mites, child, adolescent
Abstract
Background: Local allergic rhinitis (LAR) is a well-defined phenotype in adults, but still there is little data available on children. This scarcity of data can be partly attributed to the lack of standardized protocols for Nasal Allergen Challenges (NAC) in this demographic.
Methods: 20 controls (control group) and 24 patients (rhinitis group) with allergic rhinitis diagnosis sensitized to Blomia tropicalis (Bt) underwent the NAC with Bt. The acoustic rhinometry was performed after instillation of increasing concentrations of Bt (5,000 BU/mL).
Results: The median reduction in the volume of the nasal cavity in its first five centimeters (V5) by the conclusion of the NAC in the rhinitis group was markedly higher than that observed in the control group, at −22.9% (range: −21.1% to −26.2%) compared to −7.7% (ranging: −4.8% to +12.8%).
Conclusions: Our research demonstrates the efficacy and safety of the NAC protocol utilizing Bt in distinguishing allergic from non-allergic children.
References
2 Caraballo L, Zakzuk J, Lee BW, Acevedo N, Soh JY, Sánchez-Borges M, et al. Particularities of allergy in the Tropics. World Allergy Organ J. 2016;9(1):20. 10.1186/s40413-016-0110-7
3 Arruda LK, Rizzo MC, Chapman MD, Fernandez-Caldas E, Baggio D, Platts-Mills TAE, et al. Exposure and sensitization to dust mite allergens among asthmatic children in São Paulo, Brazil. Clin Exp Allergy. 1991;21(4):433–9. 10.1111/j.1365-2222.1991.tb01683.x
4 Stanaland BE, Fernández-Caldas E, Jacinto CM, Trudeau WL, Lockey RF. Positive nasal challenge responses to Blomia tropicalis. J Allergy Clin Immunol. 1996;97(5):1045–9. 10.1016/s0091-6749(96)70256-7
5 Wang DY, Goh DYT, Ho AKL, Chew FT, Yeoh KH, Lee BW. The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis. Allergy. 2003;58(1):78–82. 10.1034/j.1398-9995.2003.23746.x
6 Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy. 2008;63(Suppl 86):8–160. 10.1111/j.1398-9995.2007.01620.x
7 Hilberg O, Pedersen OF. Acoustic rhinometry: Recommendations for technical specifications and standard operating procedures. Rhinol Suppl. 2000;16:3–17.
8 Wandalsen GF, Mendes AI, Matsumoto F, Solé D. Acoustic rhinometry in nasal provocation tests in children and adolescents. J Investig Allergol Clin Immunol. 2016;26(3):156–60. 10.18176/jiaci.0036
9 Matsumoto FY, Gonçalves TRT, Solé D, Wandalsen GF. Specific nasal provocation test with Dermatophagoides pteronyssinus, monitored by acoustic rhinometry, in children with rhinitis. Am J Rhinol Allergy. 2017;31(1):7–11. 10.2500/ajra.2017.31.4392
10 Augé J, Vent J, Agache I, Airaksinen L, Campo Mozo P, Chaker A, et al. EAACI Position paper on the standardization of nasal allergen challenges. Allergy. 2018;73(8):1597–608. 10.1111/all.13416
11 Cho SH, Nanda A, Keswani A, Adinoff A, Baroody FM, Bernstein JA, et al. Nasal allergen challenge (NAC): Practical aspects and applications from an EU/US perspective—A Work Group Report of the AAAAI Rhinitis, Rhinosinusitis and Ocular Allergy Committee. J Allergy Clin Immunol. 2023;151(5):1215–22. 10.1016/j.jaci.2023.02.014
12 Hossenbaccus L, Ellis AK. Expert review of clinical immunology the use of nasal allergen vs allergen exposure chambers to evaluate allergen immunotherapy. Expert Rev Clin Immunol. 2021;17(5):461–70. 10.1080/1744666X.2021.1905523
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.