Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma
Main Article Content
Keywords
budesonide, montelukast sodium, bronchial asthma, pulmonary function, immunoglobulin
Abstract
Background and aim: Bronchial asthma is a prevalent type of respiratory disease that affects a large proportion of pediatric patients. The purpose of this study is to further investigate the clinical effects of budesonide combined with montelukast sodium in treating bronchial asthma.
Methods: Eighty six children with bronchial asthma were equally divided into study and control groups via randomized double-blind controlled trial. The control group was treated with aerosol inhalation of budesonide combined with placebo, while the study group was treated with budesonide combined with montelukast sodium. Pulmonary function parameters, immunoglobulin, and recovery of related symptoms, along with the adverse reaction rate, were observed and compared between both groups.
Results: Before treatment, there was no marked difference in pulmonary function parameters and immunoglobulin indexes between both groups (P > 0.05). All pulmonary function indicators and immunoglobulin indexes in both groups improved following therapy, with the study group outperforming the control group (P < 0.05). The recovery time of related symptoms in the study group was shorter than that in the control group (P < 0.05). The incidence of adverse reactions in both groups was compared, with notable differences (P < 0.05).
Conclusion: Budesonide combined with montelukast sodium in the treatment of bronchial asthma has the value of clinical application and promotion.
References
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19. Allam V, Paudel KR, Gupta G, Singh SK, Vishwas S, Gulati M, et al. Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma. Environ Sci Pollut Res Int. 2022;29(42):62733–62754. 10.1007/s11356-022-21454-w
20. Diaz MA, Catalan-Caceres N, Beauperthuy TC, Domingo C, Ibañez E, Morata C, et al. Clinical features and outcomes associated with bronchial asthma among COVID-19 hospitalized patients. J Asthma Allergy. 2022;15:775–781. 10.2147/JAA.S354082
21. Lee GKC, Beeler-Marfisi J, Viel L, Piché É, Kang H, Sears W, et al. Bronchial brush cytology, endobronchial biopsy, and SALSA immunohistochemistry in severe equine asthma. Vet Pathol. 2022;59(1):100–111. 10.1177/03009858211048635
22. Feng KN, Meng P, Zou XL, Zhang M, Li HK, Yang HL, et al. IL-37 protects against airway remodeling by reversing bronchial epithelial-mesenchymal transition via IL-24 signaling pathway in chronic asthma. Respir Res. 2022;23(1):244. 10.1186/s12931-022-02167-7
23. Castro M, Chupp G. 2020 Updated asthma guidelines: bronchial thermoplasty in the management of asthma. J Allergy Clin Immunol. 2021;147(5):1638–1639. 10.1016/j.jaci.2021.02.024
24. Valladales-Restrepo LF, Saavedra-Navia JC, Montezuma-Casanova CA, Montañez-Díaz V, González-Ospina JA, Caballero-Martínez LM, et al. Satisfaction with and use of inhalation devices in patients with bronchial asthma. J Aerosol Med Pulm Drug Deliv. 2022;35(6):313–320. 10.1089/jamp.2022.0027
25. Saad EA, Elsaid AM, Shoaib RMS, Megahed KF, Elsharawy AN. MUC7 VNTR polymorphism and association with bronchial asthma in Egyptian children. Sci Rep. 2022;12(1):18910. 10.1038/s41598-022-21631-4
26. Prajapati P, Tamboli J, Surati P, Mishra A. Risk assessment-based enhanced analytical quality-by-design approach to eco-friendly and economical multicomponent spectrophotometric methods for simultaneous estimation of montelukast sodium and bilastine. J AOAC Int. 2021;104(5):1453–1463. 10.1093/jaoacint/qsab089
27. Ranjan OP, Kumar N, Dave V. Cross-linked alginate beads of montelukast sodium coated with eudragit for chronotherapy: statistical optimization, in vitro and in vivo evaluation. Curr Drug Deliv. 2022;19(10):1047–1060. 10.2174/1567201819666220221091542
28. Zheng Q, Ma D, Zhu Q, Tang S, Chen C. Effect of azelastine hydrochloride combined with montelukast sodium in the treatment of patients with allergic rhinitis. Am J Transl Res. 2021;13(8):9570–9577.
29. Azizoglu E, Ozer O, Prausnitz MR. Fabrication of pure-drug microneedles for delivery of montelukast sodium. Drug Deliv Transl Res. 2022;12(2):444–458. 10.1007/s13346-021-01047-9
30. Naqi SA, Ashfaq AH, Umar MA, Karmani JK, Arshad N. Clinical outcome of montelukast sodium in children with adenoid hypertrophy. Pak J Med Sci. 2021;37(2):362–366. 10.12669/pjms.37.2.2670
31. Zhu G, Wang L, Han S, Peng H, Tong M, Gu X, et al. Pharmacokinetics and bioequivalence study of montelukast sodium oral soluble film and chewable tablet in healthy Chinese volunteers: randomized trials under fasting and fed conditions. Ann Transl Med. 2023;11(2):93. 10.21037/atm-22-6485
32. Prajapati P, Tamboli J, Mishra A. Risk and DoE-based analytical failure mode effect analysis (AFMEA) to simultaneous estimation of montelukast sodium and bilastine by HPTLC method using enhanced AQbD approach. J Chromatogr Sci. 2022;60(6):595–605. 10.1093/chromsci/bmab107
33. Nashed D, Noureldin I, Sakur AA. New pencil graphite electrodes for potentiometric determination of fexofenadine hydrochloride and montelukast sodium in their pure, synthetic mixtures, and combined dosage form. BMC Chem. 2020;14(1):60. 10.1186/s13065-020-00716-z
2. Song Y, Wang Z, Jiang J, Piao Y, Li L, Xu C, et al. DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma. J Cell Mol Med. 2020;24(23):13739–13750. 10.1111/jcmm.15942
3. Zhou XJ, Qin Z, Lu J, Hong JG. Efficacy and safety of salmeterol/fluticasone compared with montelukast alone (or add-on therapy to fluticasone) in the treatment of bronchial asthma in children and adolescents: a systematic review and meta-analysis. Chin Med J (Engl). 2021;134(24):2954–2961. 10.1097/CM9.0000000000001853
4. Varricchi G, Modestino L, Poto R, Cristinziano L, Gentile L, Postiglione L, et al. Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma. Clin Exp Med. 2022;22(2):285–300. 10.1007/s10238-021-00750-8
5. Ravi A, Goorsenberg AWM, Dijkhuis A, Dierdorp BS, Dekker T, van Weeghel M, et al. Metabolic differences between bronchial epithelium from healthy individuals and patients with asthma and the effect of bronchial thermoplasty. J Allergy Clin Immunol. 2021;148(5):1236–1248. 10.1016/j.jaci.2020.12.653
6. Chaudhuri R, Rubin A, Sumino K, Lapa ESJR, Niven R, Siddiqui S, et al. Safety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma (BT10+): a follow-up of three randomised controlled trials. Lancet Respir Med. 2021;9(5):457–466. 10.1016/S2213-2600(20)30408-2
7. Nalini CN, Kumar V. A review of different analytical techniques for fexofenadine hydrochloride and montelukast sodium in different matrices. Crit Rev Anal Chem. 2021;51(3):232–245. 10.1080/10408347.2019.1709410
8. Li W, Wang Y, Pei Y, Xia Y. Pharmacokinetics and bioequivalence evaluation of two montelukast sodium chewable tablets in healthy Chinese volunteers under fasted and fed conditions. Drug Design Dev Ther. 2021;15:1091–1099. 10.2147/DDDT.S298355
9. Jin W, Zhao Z, Zhou D. Effect of montelukast sodium combined with budesonide aerosol on airway function and T lymphocytes in asthmatic children. Pak J Med Sci. 2022;38(5):1265–1270. 10.12669/pjms.38.5.5749
10. Dai W, Zhen N, Qin X, Cao J. Effect of momethasone furoate combined with loratadine and montelukast sodium on inflammatory factors and pulmonary function in children with allergic rhinitis. Am J Transl Res. 2022;14(10):7199–7207.
11. Chen L, Huang M, Xie N. The effect of montelukast sodium plus budesonide on the clinical efficacy, inflammation, and pulmonary function in children with cough variant asthma. Am J Transl Res. 2021;13(6):6807–6816.
12. Zhang Y, Li B. Effects of montelukast sodium plus budesonide on lung function, inflammatory factors, and immune levels in elderly patients with asthma. Ir J Med Sci. 2020;189(3):985–990. 10.1007/s11845-019-02167-5
13. Asayama K, Kobayashi T, D’Alessandro-Gabazza CN, Toda M, Yasuma T, Fujimoto H, et al. Protein S protects against allergic bronchial asthma by modulating Th1/Th2 balance. Allergy. 2020;75(9):2267–2278. 10.1111/all.14261
14. Goorsenberg AWM, d’Hooghe JNS, Srikanthan K, Ten Hacken NHT, Weersink EJM, Roelofs J, et al. Bronchial thermoplasty induced airway smooth muscle reduction and clinical response in severe asthma. The TASMA randomized trial. Am J Respir Crit Care Med. 2021;203(2):175–184. 10.1164/rccm.201911-2298OC
15. Mandlik DS, Mandlik SK. New perspectives in bronchial asthma: pathological, immunological alterations, biological targets, and pharmacotherapy. Immunopharmacol Immunotoxicol. 2020;42(6):521–544. 10.1080/08923973.2020.1824238
16. Rybka-Fraczek A, Dabrowska M, Grabczak EM, Bialek-Gosk K, Klimowicz K, Truba O, et al. Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study. Respir Res. 2021;22(1):252. 10.1186/s12931-021-01845-2
17. Wijsman PC, Goorsenberg AWM, Ravi A, d’Hooghe JNS, Dierdorp BS, Dekker T, et al. Airway inflammation before and after bronchial thermoplasty in severe asthma. J Asthma Allergy. 2022;15:1783–1794. 10.2147/JAA.S383418
18. Minagawa S, Araya J, Watanabe N, Fujimoto S, Watanabe J, Hara H, et al. Real-life effectiveness of dupilumab in patients with mild to moderate bronchial asthma comorbid with CRSwNP. BMC Pulm Med. 2022;22(1):258. 10.1186/s12890-022-02046-3
19. Allam V, Paudel KR, Gupta G, Singh SK, Vishwas S, Gulati M, et al. Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma. Environ Sci Pollut Res Int. 2022;29(42):62733–62754. 10.1007/s11356-022-21454-w
20. Diaz MA, Catalan-Caceres N, Beauperthuy TC, Domingo C, Ibañez E, Morata C, et al. Clinical features and outcomes associated with bronchial asthma among COVID-19 hospitalized patients. J Asthma Allergy. 2022;15:775–781. 10.2147/JAA.S354082
21. Lee GKC, Beeler-Marfisi J, Viel L, Piché É, Kang H, Sears W, et al. Bronchial brush cytology, endobronchial biopsy, and SALSA immunohistochemistry in severe equine asthma. Vet Pathol. 2022;59(1):100–111. 10.1177/03009858211048635
22. Feng KN, Meng P, Zou XL, Zhang M, Li HK, Yang HL, et al. IL-37 protects against airway remodeling by reversing bronchial epithelial-mesenchymal transition via IL-24 signaling pathway in chronic asthma. Respir Res. 2022;23(1):244. 10.1186/s12931-022-02167-7
23. Castro M, Chupp G. 2020 Updated asthma guidelines: bronchial thermoplasty in the management of asthma. J Allergy Clin Immunol. 2021;147(5):1638–1639. 10.1016/j.jaci.2021.02.024
24. Valladales-Restrepo LF, Saavedra-Navia JC, Montezuma-Casanova CA, Montañez-Díaz V, González-Ospina JA, Caballero-Martínez LM, et al. Satisfaction with and use of inhalation devices in patients with bronchial asthma. J Aerosol Med Pulm Drug Deliv. 2022;35(6):313–320. 10.1089/jamp.2022.0027
25. Saad EA, Elsaid AM, Shoaib RMS, Megahed KF, Elsharawy AN. MUC7 VNTR polymorphism and association with bronchial asthma in Egyptian children. Sci Rep. 2022;12(1):18910. 10.1038/s41598-022-21631-4
26. Prajapati P, Tamboli J, Surati P, Mishra A. Risk assessment-based enhanced analytical quality-by-design approach to eco-friendly and economical multicomponent spectrophotometric methods for simultaneous estimation of montelukast sodium and bilastine. J AOAC Int. 2021;104(5):1453–1463. 10.1093/jaoacint/qsab089
27. Ranjan OP, Kumar N, Dave V. Cross-linked alginate beads of montelukast sodium coated with eudragit for chronotherapy: statistical optimization, in vitro and in vivo evaluation. Curr Drug Deliv. 2022;19(10):1047–1060. 10.2174/1567201819666220221091542
28. Zheng Q, Ma D, Zhu Q, Tang S, Chen C. Effect of azelastine hydrochloride combined with montelukast sodium in the treatment of patients with allergic rhinitis. Am J Transl Res. 2021;13(8):9570–9577.
29. Azizoglu E, Ozer O, Prausnitz MR. Fabrication of pure-drug microneedles for delivery of montelukast sodium. Drug Deliv Transl Res. 2022;12(2):444–458. 10.1007/s13346-021-01047-9
30. Naqi SA, Ashfaq AH, Umar MA, Karmani JK, Arshad N. Clinical outcome of montelukast sodium in children with adenoid hypertrophy. Pak J Med Sci. 2021;37(2):362–366. 10.12669/pjms.37.2.2670
31. Zhu G, Wang L, Han S, Peng H, Tong M, Gu X, et al. Pharmacokinetics and bioequivalence study of montelukast sodium oral soluble film and chewable tablet in healthy Chinese volunteers: randomized trials under fasting and fed conditions. Ann Transl Med. 2023;11(2):93. 10.21037/atm-22-6485
32. Prajapati P, Tamboli J, Mishra A. Risk and DoE-based analytical failure mode effect analysis (AFMEA) to simultaneous estimation of montelukast sodium and bilastine by HPTLC method using enhanced AQbD approach. J Chromatogr Sci. 2022;60(6):595–605. 10.1093/chromsci/bmab107
33. Nashed D, Noureldin I, Sakur AA. New pencil graphite electrodes for potentiometric determination of fexofenadine hydrochloride and montelukast sodium in their pure, synthetic mixtures, and combined dosage form. BMC Chem. 2020;14(1):60. 10.1186/s13065-020-00716-z
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Jul 1, 2023
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Chu, F., Liang, L., & Chen, F. (2023). Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma. Allergologia Et Immunopathologia, 51(4), 151-157. https://doi.org/10.15586/aei.v51i4.897
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How to Cite
Chu, F., Liang, L., & Chen, F. (2023). Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma. Allergologia Et Immunopathologia, 51(4), 151-157. https://doi.org/10.15586/aei.v51i4.897