The traditional Mediterranean diet is effective in the prevention and treatment of acute and recurrent inflammatory diseases of childhood
Main Article Content
Keywords
Inflammatory disease, recurrent disease, recurrent colds, recurrent acute otitis media, recurrent acute rhinosinusitis, otitis media with effusion, persistent nasal obstruction, childhood asthma, Mediterranean diet, dietary intervencion, nutritional therapy
Abstract
In the recent SARS-CoV-2 pandemic, disease severity was found to be more related to the immune system hyper-response than the invasive or destructive capacity of the virus. Similarly, most common childhood diseases, which are generally recurrent and inflammatory, may be caused by a hyper-response or inability of the immune system. Individuals will react differently to causal noxa and outcomes will depend on the balance and maturity of their immune system. Conventionally, childhood diseases are symptomatically treated with little attention being devoted to balancing and stimulating the maturation of the immune system. Recently, there has been an increase in publications that consider lifestyle as an important factor in the maintenance of health. One controversial angle is an abandonment of the traditional diet and the inclusion of foods that are potentially less well-assimilated by the human species. An increasing number of studies are demonstrating the anti-inflammatory effects of the Mediterranean Diet while illustrating the pro-inflammatory effects of many other food types. We believe that the Traditional Mediterranean Diet consists of foods that support the establishment and maintenance of a healthy microbiota and a mature immune system that, in turn, can aid in the prevention of common inflammatory and recurrent diseases of childhood.
References
2. Marcos A. Editorial: A review of micronutrients and the immune system—Working in harmony to reduce the risk of infection. Nutrients. 2021;13(11):4180. 10.3390/nu13114180
3. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the immune system–Working in harmony to reduce the risk of infection. Nutrients. 2020;12(1):236. 10.3390/nu12010236
4. Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients. 2020;12(4):1181. 10.3390/nu12041181
5. Childs CE, Calder PC, Miles EA. Diet and immune function. Nutrients. 2019;11(8):1933. 10.3390/nu11081933
6. NIDA. Overview. National Institute on Drug Abuse website. Available from: https://www.drugabuse.gov/publications/research-reports/misuse-prescription-drugs/overview. Accessed November 18, 2021.
7. UNESCO. Mediterranean diet. Representative list of the intangible cultural heritage of humanity. Cyprus, Croatia, Spain, Greece, Italy, Morocco, Portugal. 2013. Available from: http://www.unesco.org/culture/ich/es/RL/00884
8. Bach-Faig A, Berry EM, Lairon D, Reguant J, Trichopoulou A, Dernini S, et al. Mediterranean Diet Foundation Expert Group. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr. 2011;14(12A):2274–84. 10.1017/S1368980011002515
9. García-Marcos L, Castro-Rodríguez JA, Weinmayr G, Panagiotakos DB, Priftis KN, Nagel G. Influence of Mediterranean diet on asthma in children: A systematic review and meta-analysis. Pediatr Allergy Immunol. 2013;24:330–8. 10.1111/pai.12071
10. García-Marcos L. Mediterranean diet as a protection against asthma: Still another brick in building a causative association. Allergol Immunopathol (Madr). 2016;44(2):97–8. 10.1016/j.aller.2016.02.001
11. Bach-Faig A, Berry EM, Lairon D, Reguant J, Trichopoulou A, Dernini S, et al. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr. 2011;14(12A):2274–84. 10.1017/S1368980011002515
12. Castro-Rodríguez JA. What are the real effects of the Mediterranean diet on recurrent colds and their complications? Allergol Immunopathol (Madr). 2017;45(5):415–6. 10.1016/j.aller.2017.02.002
13. Calatayud-Sáez F, Calatayud B, Gallego JG, González-Martín C, Alguacil LF. Effects of Mediterranean diet in patients with recurring colds and frequent complications. Allergol et immunopathol (Madr). 2017;45(5):417–24. 10.1016/j.aller.2016.08.006
14. Calatayud-Sáez FM, Calatayud B, and Calatayud A. Recurrent acute otitis media could be related to the pro-inflammatory state that causes an incorrect diet. Progr Nutr. 2021. Pending publication.
15. Calatayud-Sáez FM, Calatayud B, Calatayud A. Effects of the traditional Mediterranean diet in childhood recurrent acute rhinosinusitis. Sinusitis. 2021;5(2):101–15. 10.3390/sinusitis5020011
16. Calatayud-Sáez FM, Calatayud B, and Calatayud A. Effects of the traditional Mediterranean diet in patients with otitis media with effusion. Nutrients. 2021;13:2181. 10.3390/nu13072181
17. Calatayud-Sáez FM, Calatayud B, and Calatayud A. Persistent nasal obstruction: An expression of the pro-inflammatory state? Sinusitis. 2021;5:90–100. 10.3390/sinusitis5010010
18. Calatayud-Sáez FM, Calatayud B, Gallego JG, González-Martín C, Alguacil-Merino LF. Mediterranean diet and childhood asthma. Allergol Immunopathol (Madr). 2016;44(2):99–105. 10.1016/j.aller.2015.04.007
19. Calatayud-Sáez FM, Calatayud B, Luque M, Calatayud A, Gallego JG, Rivas F. Effects of affinity to the Mediterranean Diet pattern along with breastfeeding on childhood asthma, inflammatory and recurrent diseases in an intervention study. Allergol Immunopathol (Madr). 2021;49(6):48–55. 10.15586/aei.v49i6.338
20. Calatayud-Sáez FM, Calatayud B, Calatayud A. Effects of the Mediterranean diet on morbidity from inflammatory and recurrent diseases with special reference to childhood asthma. Nutrients. 2022, 14, 936. 10.3390/nu14050936
21. González-Gil EM, Tognon G, Lissner L, Intemann T, Pala V, Galli C, et al. Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: The IDEFICS study. Eur J Nutr. 2018;57(4):1397–407. 10.1007/s00394-017-1419-x
22. Venter C, Eyerich S, Sarin T, Klatt KC. Nutrition and the immune system: A complicated tango. Nutrients. 2020;12(3): 818. 10.3390/nu12030818
23. Nomikos T, Fragopoulou E, Antonopoulou S, Panagiotakos DB. Mediterranean diet and platelet-activating factor; systematic review. Clin Biochem. 2018;60:1–10. 10.1016/j.clinbiochem.2018.08.004