Steroid-sparing effect of mepolizumab in children with severe eosinophilic nonallergic asthma

Main Article Content

Maria Angela Tosca
Donata Girosi
Oliviero Sacco
Roberto Bernardini
Giorgio Ciprandi

Keywords

bronchial endoscopy, children, eosinophils, mepolizumab, severe asthma

Abstract

Background: Asthma is characterized by a chronic airway inflammation, usually sustained by type 2 immunity. Bronchial and peripheral eosinophilia are biomarkers for type 2 asthma. Biologicals are the most effective treatment for severe asthma at present. Mepolizumab is an antagonist of interleukin-5 (IL-5), the most relevant cytokine involved in eosinophilia.


Objective: This case report evaluated the effectiveness of mepolizumab in two girls with severe eosinophilic non-allergic asthma.


Materials and methods: Two female children with severe eosinophilic nonallergic asthma were treated with mepolizumab for two years. Clinical findings, lung function, peripheral eosinophils, asthma control, and bronchial endoscopy were performed.


Results: Biologicals reduced the eosinophilia, asthma exacerbations, and improved lung function in both patients. The treatment was also safe and well-tolerated.


Conclusion: Mepolizumab represents an effective therapeutic option in the management of severe pediatric asthma.

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