Oral allergy syndrome by fruit and vegetable PR-10 allergy: Accuracy of in vivo diagnosis

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Cristina De Rose
Maria Letitzia Patti
Alessadro Gambacorta
Federica Brancato
Stefano Miceli Sopo


Component-resolved diagnosis, oral allergy syndrome, prick by prick, PR-10 allergy, skin prick test


Routine diagnostic methods for allergies to plant-derived foods are based on skin prick test (SPT) with commercial extracts, prick-by-prick (PbP) with fresh food, serum-specific IgE measurement, and oral food challenge.
We discuss the possibility and the advantages of performing, in patients with oral allergy syn-drome (OAS) by fruit and vegetables (excluding nuts) PR-10 allergy, component-resolved diag-nosis (CRD) by SPT and PbP with raw and cooked vegetables, rather than performing a CRD with in vitro tests by drawing blood.
Based on our clinical experience and the studies published in the literature, we believe that, at least for the OAS by fruit and vegetables (excluding nuts) PR-10 allergy, the search for sensitizing allergens and related cross-reactive allergens with SPT and PbP can be performed routinely in clinical practice, even at the primary-care level.

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