Effect of Qingchang Yuyang decoction on treatment efficacy and intestinal flora in patients with ulcerative colitis
Main Article Content
Keywords
intestinal flora, Qingchang Yuyang decoction, traditional Chinese medicine syndrome score, ulcerative colitis
Abstract
This study investigates the therapeutic effects of Qingchang Yuyang Decoction on ulcerative colitis (UC) and its impact on intestinal flora. Using existing case records, a retrospective analysis was conducted utilizing clinical data from 96 UC patients (damp-heat syndrome of the large intestine) treated at our hospital between June 2022 and June 2024. Based on the different treatment methods recorded, 50 patients were included in the observation group and 46 in the control group. The control group received conventional treatment (oral sustained-release mesalazine tablets), while the observation group received oral Qingchang Yuyang Decoction in addition to conventional treatment. The efficacy and effects on intestinal flora were compared between the two groups. The change in the modified Mayo score before and after treatment in the observation group was significantly greater than that in the control group (p < 0.001). After treatment, scores for abdominal pain and diarrhea, mucus-pus-bloody stools, tenesmus, anal burning, and short and red urine were significantly lower in the observation group compared to the control group (p < 0.05). Post-treatment, the observation group showed significantly higher levels of IL-10 than the control group, while IL-8 and TNF-α levels were lower in the observation group (p < 0.05). After treatment, Enterococcus and Enterobacter counts in the observation group were lower, while the observation group had higher levels of Bifidobacterium, Butyric Clostridium, and Lactobacillus compared to the control group (p < 0.05). The complication rate was lower in the observation group (p < 0.05). The combination of Qingchang Yuyang Decoction with sustained-release mesalazine tablets can improve the clinical efficacy in UC, significantly alleviate clinical symptoms, reduce the inflammatory response, adjust intestinal flora distribution, and promote recovery, making it worthy of clinical application.
References
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19 Bao Y, Hu SN, Song ZJ, Shen HJ, Zhong WL, Du SY. Chinese medicine Di-Long (Pheretima vulgaris) and its active fraction exhibit anti-rheumatoid arthritis effects by inhibiting CXCL10/CXCR3 chemotaxis in synovium. J Ethnopharmacol. 2024;332:118286. 10.1016/j.jep.2024.118286
20 Kharangate K, Shende P. A stimuli-responsive keratin functionalized PEI coated baicalin nano-hydrogels for modulated gastric ulcer therapy. Colloids Surf A Physicochem Eng Asp. 2025;705(P1):135541. 10.1016/j.colsurfa.2024.135541
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22 Jia-Chen X, Shuo Y, Huan M, Xiao-Ting H, Jiao L, Hua-Min Z, et al. The role and mechanism of flavonoid herbal natural products in ulcerative colitis.Biomed Pharmacother. 2023;158:114086. 10.1016/j.biopha.2022.114086
23 Imtiyaz NA, Archana S, Abdulrahman A, Thamer H A, Metab A, Taief AD, et al. Anti-oxidant and anti-inflammatory potential of different polymer-based mesalamine delayed-release granules in TNBS-induced ulcerative colitis in wistar rats. Saudi Pharm J. 2024;32(1):101910. 10.1016/j.jsps.2023.101910
24 Kun L, Tianshuang X, Yiping J, Nani W, Liyong L, Shengyan X, et al. A review on ethnopharmacology, phytochemistry, pharmacology and potential uses of Portulaca oleracea L. J Ethnopharmacol. 2023.319(P2):117211-117211.
25 Hao Y, Zhang X, Lin X, Shasha Y, You H, Wenjing L, et al. The traditional Chinese medicine processing change chemical composition and pharmacological effectiveness: Taking Atractylodes macrocephala Koidz. and honey bran-fried Atractylodes macrocephala Koidz. as examples. Phytomedicine. 2024;130:155739.
26 Dou J, Zhang H, HAO H, Mengxiong L, Jing M, Zhihong L. et al. Clinical Effect of Modified Gegen Qinlian Decoction Combined with Western Medicine on Children with Rotavirus Enteritis with Damp-Heat Syndrome. Xi’an Daxing Hospital; Gaoling Maternal and Child Health Hospital; The Second Affiliated Hospital of Shaanxi University of Chinese Medicine.2024;15(6).
27 Paola RS, López HA, Eduardo PJ. Gene expression of pro-inflammatory (IL-8, IL-18, TNF-α, and IFN-γ) and anti-inflammatory (IL-10) cytokines in the duodenum of broiler chickens exposed to lipopolysaccharides from Escherichia coli and Bacillus subtilis. Vet World. 2023;16(3):564-70.
28 Meiqin S, Yingqi S, Zhenming G, Junbo Q. Effects of Mesalamine Combined with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules on Intestinal Mucosa Barrier Function and Intestinal Microbiota in Mildly Active Crohn’s Disease Patients. J Invest Surg. 2024;37(1):2297565.
29 Leng D A. Comprehensive Review on Botany, Phytochemistry, Traditional Uses, Pharmacology, Analytical Methods, Processing Methods, Pharmacokinetics and Toxicity of Pulsatilla chinensis. Altern Therap Health Med. 2024;30(1):374-380.
30 Li P, Chen L, Liu J. Network pharmacology and molecular docking approach to elucidate the mechanisms of safflower, phellodendron, scutellaria baicalensis, coptis, and gardenia in hand–foot syndrome. Front Med. 2024.11:1454776.
31 Zhao Y, Du Y, Zhang H, et al.A New Alkaloid from Portulaca oleracea and Its Anti-Inflammatory and Antioxidant Activities. Chem Nat Compd. 2025;61(1):1-5.
32 Si-min C, Guang-ye J, Xu-ran L, Meng-juan Y, Yi-nuo Z, Jing C, et al. Efficacy of integrated traditional Chinese and Western medicine on ulcerative colitis: a systematic review and meta-analysis Pharmacol Res Mod Chin Med. 2022;4.
33 Pang L W, Li G T, Wang Y Y, Li-Yun S, Li L, Xiao-Ya L, et al. Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity. Front Cell Infect Microbiol. 2025;15:1528578.
34 Han L, Tang K, Fang L X, Meng-jun X, Xiao-bin Z, Xiao-jing Z, et al. Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway. World J Gastrointest Surg. 2024;16(4):1149-1154. 10.3389/fcimb.2025.1528578
35 Liang C, Chen S, Liu C, Lirong W, Huan C, Kunze D, et al. Active components unveiling and pharmacodynamic research on Valeriana jatamansi Jones for ameliorating ulcerative colitis based on pharmacokinetics and network pharmacology. J Cthnopharmacol. 2024;341:119299. 10.1016/j.jep.2024.119299
36 Li X, Wang Z, Gao H, Ying X, Peng J, Yan-Ming W, et al. Pulsatillae radix extract alleviates DSS-induced colitis via modulating gut microbiota and inflammatory signaling pathway in mice. Heliyon. 2023;9(11):e21869. 10.1016/j.heliyon.2023.e21869
37 Shaban SF, Abdel-Fattah EA, Ali MM, Dessouky AA. The therapeutic efficacy of adipose mesenchymal stem cell-derived microvesicles versus infliximab in a dextran sodium sulfate induced ulcerative colitis rat model. Ultrastruct Pathol. 2024;48(6):526-549. 10.1080/01913123.2024.2426566
38 Yang Y, Xiechen Z, Guiyan J, Hui Z, Yan L, Junyang C, et al. Portulaca oleracea L. polysaccharide ameliorates ulcerative colitis by regulating the immune system and gut microbiota. Food Bioscience. 2024;(61). 10.1016/j.fbio.2024.104926
39 Zhang, Q.-W., Yang, Chun-YL, >Reham T, Qing-Yu L, Mohammed IA, et al. Atractylodes macrocephala Koidz polysaccharide ameliorates DSS-induced colitis in mice by regulating the gut microbiota and tryptophan metabolism. Br J Pharmacol. 2024. 10.1111/bph.17409
40 Khan A, Abass S, Nizami S A I, Mohd S, Sultan Z, Bushra P, et al. The Gut Health Revolution: Herbs and Dietary Phytochemicals in Balancing Gut Microbiota for Optimal Human Health. Curr Pharm Biotechnol. 2024. 10.2174/0113892010313921240923125946
41 Shi JY, Wang YJ, Bao QW, Xue-Qiang Z, Li-Hua P, Qiang-Ming L, et al. Polygonatum cyrtonema Hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response. Carbohydr Polym. 2025;356:123387. 10.1016/j.carbpol.2025.123387
2 Matsuoka K, Hibiya S, Ando K, Tani Y, Torisu T, Ogino H, et al. A Continuous Registry of Medical Record, Patient Input, and Epidemiological Data of Patients With Ulcerative Colitis: a Multicentre, Prospective, Observational Clinical Registry Study in Japan. Ann Clin Epidemiol. 2024;6(3):65-72. 10.37737/ace.24010
3 Manuel BA, Alberto M, Esther A, Silvia D, Luis L, David dPH, et al. Epidemiological, Clinical, Patient-Reported and Economic Burden of Inflammatory Bowel Disease (Ulcerative colitis and Crohn’s disease) in Spain: A Systematic Review. Adv Ther. 2023;40(5):1975-2014. 10.1007/s12325-023-02473-6
4 Majzoub ME, Paramsothy S, Haifer C, Parthasarathy R, Borody TJ, Leong RW, et al. The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission. Nat Commun. 2024;15(1):8979. 10.1038/s41467-024-53454-4
5 Haixia L, Jing L, Jiaxin Y, Jinke H, Youqi X. Fecal microbiota transplantation as a therapy for treating ulcerative colitis: an overview of systematic reviews. BMC Microbiol. 2023;23(1):371. 10.1186/s12866-023-03107-1
6 Zhu Q, Liu L. Research Progress of Chinese Medicine in Regulating Relevant Signalling Pathways for the Treatment of Ulcerative Colitis. J Contemp Med Pract. 2024;6(8):94-8. 10.53469/jcmp.2024.06(08).20
7 Sun D, Zhang Z, Xue J. MiRNAs: a new target for Chinese medicine to repair the intestinal barrier in the treatment of ulcerative colitis. Front Pharmacol. 2024;15:1446554. 10.3389/fphar.2024.1446554
8 Steffen H, Joseph M. Comment on the 2023 ACG Guideline for Celiac Disease. The Am J Gastroenterol. 2023;118(6):1102. 10.14309/ajg.0000000000002230
9 D’Amico F, Magro F, Dignass A, Awadhi SA, Casbas AG, Queiroz NSF, et al. Practical management of mild-to-moderate ulcerative colitis: an international expert consensus. Expert Rev Gastroenterol Hepatol. 2024:11-0. 10.1080/17474124.2024.2397650
10 Anita M, Jurgen LLEP, Jin Y Jin, Matts Kågedal, Nastya Kassir. A Disease Model Predicting Placebo Response and Remission Status of Patients with Ulcerative Colitis Using Modified Mayo Score. Clin Transl Sci. 2023;16(11):2310-2322. 10.1111/cts.13632
11 Park J, Zhang HS, Nam CM, Kim JS, Kim YH, Park DI, et al. Development and Assessment of a Novel Ulcerative Colitis-Specific Quality of Life Questionnaire: A Prospective, Multi-Institutional Study. Yonsei Med J. 2024;65(11):636-44. 10.3349/ymj.2023.0503
12 Salvatore M, Mauro D, Francesca OM, Marcello P, Walter E, Manuela M, et al. Clinical and epidemiological features of ulcerative colitis patients in Sardinia, Italy: Results from a multicenter study. World J Clin Cases. 2022;10(30):10921-30. 10.12998/wjcc.v10.i30.10921
13 Irēna T, Viktorija M, Eva P, Juris P. Burden of extraintestinal manifestations and comorbidities in treated and untreated ulcerative colitis and Crohn’s disease: a Latvian nationwide prescription database study 2014–2019. Proc Latv Acad Sci B. 2022;76(5-6):608-17. 10.2478/prolas-2022-0094
14 Zsuzsanna K, Lorant G, Laszlo L, Petra G, Tunde P, Gyula D, et al. Epidemiology, treatment strategy, natural disease course and surgical outcomes of patients with ulcerative colitis in Western Hungary-a population-based study between 2007 and 2018, data from the Veszprem County cohort. J Crohn’s Colitis. 2022;17(3). 10.1093/ecco-jcc/jjac142
15 Mi SE, Arum C, Sukil K, Hoon JS. The Prevalence and Risk Factors of Clostridioides difficile Infection in Inflammatory Bowel Disease: 10-Year South Korean Experience Based on the National Database. J Korean Med Sci. 2023;38(47):e359-e. 10.3346/jkms.2023.38.e359
16 Bahrami S, Babaei N, Ghaleh HEG, Borazjani JM, Farzanehpour M. Investigating the effects of combined treatment of mesalazine with Lactobacillus casei in the experimental model of ulcerative colitis. Front Mol Biosci. 2024;11:1456053. 10.3389/fmolb.2024.1456053
17 Xie F, Zhang Y, Wang T. Effects of mesalazine suppository combined with Kangfuxin solution retention enema on inflammatory markers and adverse reactions in patients with active ulcerative colitis. Minerva Gastroenterol. 2024. 10.23736/S2724-5985.24.03720-3
18 Maituoheti R, Rouzimaimaiti R, Xu NN, Zhao J, Aisa HA. seco-iridoid glycosides and flavonoid glycosides from the Gentiana olivieri Griseb and their anti-inflammatory activities. Fitoterapia. 2024;177:106049. 10.1016/j.fitote.2024.106049
19 Bao Y, Hu SN, Song ZJ, Shen HJ, Zhong WL, Du SY. Chinese medicine Di-Long (Pheretima vulgaris) and its active fraction exhibit anti-rheumatoid arthritis effects by inhibiting CXCL10/CXCR3 chemotaxis in synovium. J Ethnopharmacol. 2024;332:118286. 10.1016/j.jep.2024.118286
20 Kharangate K, Shende P. A stimuli-responsive keratin functionalized PEI coated baicalin nano-hydrogels for modulated gastric ulcer therapy. Colloids Surf A Physicochem Eng Asp. 2025;705(P1):135541. 10.1016/j.colsurfa.2024.135541
21 Jialing Z, Jiashuai D, Nana W, Ping W, Ji L, Yunhai W, et al. Quality of reporting of integrative Chinese and Western medicine intervention in randomized controlled trials of ulcerative colitis: a review. Syst Rev. 2023;12(1):228. 10.1186/s13643-023-02402-2
22 Jia-Chen X, Shuo Y, Huan M, Xiao-Ting H, Jiao L, Hua-Min Z, et al. The role and mechanism of flavonoid herbal natural products in ulcerative colitis.Biomed Pharmacother. 2023;158:114086. 10.1016/j.biopha.2022.114086
23 Imtiyaz NA, Archana S, Abdulrahman A, Thamer H A, Metab A, Taief AD, et al. Anti-oxidant and anti-inflammatory potential of different polymer-based mesalamine delayed-release granules in TNBS-induced ulcerative colitis in wistar rats. Saudi Pharm J. 2024;32(1):101910. 10.1016/j.jsps.2023.101910
24 Kun L, Tianshuang X, Yiping J, Nani W, Liyong L, Shengyan X, et al. A review on ethnopharmacology, phytochemistry, pharmacology and potential uses of Portulaca oleracea L. J Ethnopharmacol. 2023.319(P2):117211-117211.
25 Hao Y, Zhang X, Lin X, Shasha Y, You H, Wenjing L, et al. The traditional Chinese medicine processing change chemical composition and pharmacological effectiveness: Taking Atractylodes macrocephala Koidz. and honey bran-fried Atractylodes macrocephala Koidz. as examples. Phytomedicine. 2024;130:155739.
26 Dou J, Zhang H, HAO H, Mengxiong L, Jing M, Zhihong L. et al. Clinical Effect of Modified Gegen Qinlian Decoction Combined with Western Medicine on Children with Rotavirus Enteritis with Damp-Heat Syndrome. Xi’an Daxing Hospital; Gaoling Maternal and Child Health Hospital; The Second Affiliated Hospital of Shaanxi University of Chinese Medicine.2024;15(6).
27 Paola RS, López HA, Eduardo PJ. Gene expression of pro-inflammatory (IL-8, IL-18, TNF-α, and IFN-γ) and anti-inflammatory (IL-10) cytokines in the duodenum of broiler chickens exposed to lipopolysaccharides from Escherichia coli and Bacillus subtilis. Vet World. 2023;16(3):564-70.
28 Meiqin S, Yingqi S, Zhenming G, Junbo Q. Effects of Mesalamine Combined with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules on Intestinal Mucosa Barrier Function and Intestinal Microbiota in Mildly Active Crohn’s Disease Patients. J Invest Surg. 2024;37(1):2297565.
29 Leng D A. Comprehensive Review on Botany, Phytochemistry, Traditional Uses, Pharmacology, Analytical Methods, Processing Methods, Pharmacokinetics and Toxicity of Pulsatilla chinensis. Altern Therap Health Med. 2024;30(1):374-380.
30 Li P, Chen L, Liu J. Network pharmacology and molecular docking approach to elucidate the mechanisms of safflower, phellodendron, scutellaria baicalensis, coptis, and gardenia in hand–foot syndrome. Front Med. 2024.11:1454776.
31 Zhao Y, Du Y, Zhang H, et al.A New Alkaloid from Portulaca oleracea and Its Anti-Inflammatory and Antioxidant Activities. Chem Nat Compd. 2025;61(1):1-5.
32 Si-min C, Guang-ye J, Xu-ran L, Meng-juan Y, Yi-nuo Z, Jing C, et al. Efficacy of integrated traditional Chinese and Western medicine on ulcerative colitis: a systematic review and meta-analysis Pharmacol Res Mod Chin Med. 2022;4.
33 Pang L W, Li G T, Wang Y Y, Li-Yun S, Li L, Xiao-Ya L, et al. Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity. Front Cell Infect Microbiol. 2025;15:1528578.
34 Han L, Tang K, Fang L X, Meng-jun X, Xiao-bin Z, Xiao-jing Z, et al. Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway. World J Gastrointest Surg. 2024;16(4):1149-1154. 10.3389/fcimb.2025.1528578
35 Liang C, Chen S, Liu C, Lirong W, Huan C, Kunze D, et al. Active components unveiling and pharmacodynamic research on Valeriana jatamansi Jones for ameliorating ulcerative colitis based on pharmacokinetics and network pharmacology. J Cthnopharmacol. 2024;341:119299. 10.1016/j.jep.2024.119299
36 Li X, Wang Z, Gao H, Ying X, Peng J, Yan-Ming W, et al. Pulsatillae radix extract alleviates DSS-induced colitis via modulating gut microbiota and inflammatory signaling pathway in mice. Heliyon. 2023;9(11):e21869. 10.1016/j.heliyon.2023.e21869
37 Shaban SF, Abdel-Fattah EA, Ali MM, Dessouky AA. The therapeutic efficacy of adipose mesenchymal stem cell-derived microvesicles versus infliximab in a dextran sodium sulfate induced ulcerative colitis rat model. Ultrastruct Pathol. 2024;48(6):526-549. 10.1080/01913123.2024.2426566
38 Yang Y, Xiechen Z, Guiyan J, Hui Z, Yan L, Junyang C, et al. Portulaca oleracea L. polysaccharide ameliorates ulcerative colitis by regulating the immune system and gut microbiota. Food Bioscience. 2024;(61). 10.1016/j.fbio.2024.104926
39 Zhang, Q.-W., Yang, Chun-YL, >Reham T, Qing-Yu L, Mohammed IA, et al. Atractylodes macrocephala Koidz polysaccharide ameliorates DSS-induced colitis in mice by regulating the gut microbiota and tryptophan metabolism. Br J Pharmacol. 2024. 10.1111/bph.17409
40 Khan A, Abass S, Nizami S A I, Mohd S, Sultan Z, Bushra P, et al. The Gut Health Revolution: Herbs and Dietary Phytochemicals in Balancing Gut Microbiota for Optimal Human Health. Curr Pharm Biotechnol. 2024. 10.2174/0113892010313921240923125946
41 Shi JY, Wang YJ, Bao QW, Xue-Qiang Z, Li-Hua P, Qiang-Ming L, et al. Polygonatum cyrtonema Hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response. Carbohydr Polym. 2025;356:123387. 10.1016/j.carbpol.2025.123387
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May 1, 2025
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Wang, J., Cao, L., & Zhu, Y. (2025). Effect of Qingchang Yuyang decoction on treatment efficacy and intestinal flora in patients with ulcerative colitis. Allergologia Et Immunopathologia, 53(3), 60-71. https://doi.org/10.15586/aei.v53i3.1332
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How to Cite
Wang, J., Cao, L., & Zhu, Y. (2025). Effect of Qingchang Yuyang decoction on treatment efficacy and intestinal flora in patients with ulcerative colitis. Allergologia Et Immunopathologia, 53(3), 60-71. https://doi.org/10.15586/aei.v53i3.1332