Genetic predisposition and increased environmental allergen exposure in cat allergy: The pandemic is a very good example
Main Article Content
Keywords
pandemic, cat allergy, sensitization, hypersensitivity, indoor allergens, COVID-19
Abstract
Objective: Domestic cats are among the most common sources of indoor allergens. There was an increase in indoor allergen exposure, especially cats and house dust mites, as people spent more time at home during the COVID-19 pandemic lockdowns. In this study, our aim was to examine the frequency of cat sensitization and ownership after the COVID-19 pandemic and its relationship with other indoor and pollen allergen sensitizations.
Methods: The data of patients who applied to our clinic between 2018 and 2022, with a history of hypersensitivity reaction after contact with cats and diagnosed with cat allergy by positive skin test or specific immunoglobulin E (sIgE) level, were examined retrospectively. Skin test was performed in accordance with the manufacturer’s instructions. sIgE levels against cat allergens were measured using The Phadia CAP System FEIA method.
Results: There has been an increase in the rate of cat ownership (P < 0.001) during the COVID-19 pandemic. The prevalence of cat allergy in 2020 and beyond (5.89%) was significantly higher than the pre-COVID period (4.53%; P < 0.001). The prevalence of concomitant df (dermatophagoides farinae) (1.53–1.58%), dp (dermatophagoides pterynossinus) (1.53–1.48%), and pollen (3.47–3.62%) hypersensitivity before COVID-19 did not differ significantly after COVID, but the prevalence of “penicillium” hypersensitivity before COVID (= 8/5825) was found to be significantly lower (0.14–1.28%).
Conclusion: During the pandemic period, both the increase in cat ownership and spending more time indoors seem to have led to an increase in cat allergy. No increase in indoor allergen sensitization other than penicillium accompanying cat allergy was detected.
References
2 “Fediaf. FEDIAF European Pet Food.” Accessed 30.04.2024. https://www.dropbox.com/s/h3vapzfju5j8vei/Facts%20and%20Figures%202021.pdf?dl=0.
3 Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S, et al. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: Novel sensitization patterns for inhalant allergens in Europe. Allergy 2009;64(10):1498–1506. 10.1111/j.1398-9995.2009.02093.x
4 Yilmaz I, Oner Erkekol F, Secil D, Misirligil Z, Mungan D. Cat and dog sensitization in pet shop workers. Occup Med (Lond) 2013;63(8):563–7. 10.1093/occmed/kqt116
5 Mungan D, Celik G, Bavbek S, Misirligil Z. Pet allergy: How important for Turkey where there is a low pet ownership rate. Allergy Asthma Proc 2003;24(2):137–42.
6 Dávila I, Domínguez-Ortega J, Navarro-Pulido A, Alonso A, Antolín-Amerigo D, González-Mancebo E, et al. Consensus document on dog and cat allergy. Allergy 2018;73(6):1206–22. 10.1111/all.13391
7 Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: Immunity, inflammation and intervention. Nat Rev Immunol 2020;20(6):363–74. 10.1038/s41577-020-0311-8
8 Centers for Disease Control and Prevention. COVID-19 weekly cases and deaths per 100,000 population by age, race/ethnicity, and sex. 2023. In. Available from: https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm.
9 Organization WH. WHO Director-General’s opening remarks at the media briefing on COVID-19–11 March 2020. In. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020.
10 Li Y, Hu H, Zhang T, Wang G, Huang H, Zheng P, et al. Increase in indoor inhalant allergen sensitivity during the COVID-19 pandemic in South China: A cross-sectional study from 2017 to 2020. J Asthma Allergy 2021;14:1185–95. 10.2147/JAA.S322034
11 Liu Y, Yang S, Zeng Y, Yang C, Li X, Zong X, et al. Influence of the COVID-19 pandemic on the prevalence pattern of allergens. Int Arch Allergy Immunol 2023;184(1):43–53. 10.1159/000526892
12 Buyuk YS, Metbulut AP, Giniş T, Toyran M, Civelek E, Dibek ME. Cat allergy in children and the effect of the COVID-19 pandemic. Allergy Asthma Proc 2022;43(5):e31–9. 10.2500/aap.2022.43.220037
13 Evcen R, Çölkesen F, Yıldız E, Sadi Aykan F, Kılınç M, Akkuş FA, et al. Increasing prevalence of sensitization to cat/dog allergens in the COVID-19 pandemic. Int Arch Allergy Immunol 2024;185(2):133–41. 10.1159/000534173
14 Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA 2002;288(8):963–72. 10.1001/jama.288.8.963
15 Hesselmar B, Aberg N, Aberg B, Eriksson B, Björkstén B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999;29(5):611–7. 10.1046/j.1365-2222.1999.00534.x
16 Arshad SH. Primary prevention of asthma and allergy. J Allergy Clin Immunol 2005;116(1):3–14; quiz 15. 10.1016/j.jaci.2005.03.043
17 Meng SS, Gao R, Yan BD, Ren J, Wu F, Chen P, et al. Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells. Respir Res 2016;17(1):114. 10.1186/s12931-016-0430-8
18 Olivieri M, Zock JP, Accordini S, Heinrich J, Jarvis D, Künzli N, et al. Risk factors for new-onset cat sensitization among adults: A population-based international cohort study. J Allergy Clin Immunol 2012;129(2):420–5. 10.1016/j.jaci.2011.10.044
19 Chen Y, Pu X, Chen J, Wang X, Wang H, Wang X. Sensitization pattern of cat and dog dander allergen in 16,426 patients with allergic diseases. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021;35(4):333–7.
20 Custovic A. To what extent is allergen exposure a risk factor for the development of allergic disease? Clin Exp Allergy 2015;45(1):54–62. 10.1111/cea.12450
21 Grant T, Rule AM, Koehler K, Wood RA, Matsui EC. Sampling devices for indoor allergen exposure: Pros and cons. Curr Allergy Asthma Rep 2019;19(1):9. 10.1007/s11882-019-0833-y
22 Erwin EA, Woodfolk JA, Custis N, Platts-Mills TA. Animal danders. Immunol Allergy Clin North Am 2003;23(3):469–81. 10.1016/S0889-8561(03)00004-3
23 Custis NJ, Woodfolk JA, Vaughan JW, Platts-Mills TA. Quantitative measurement of airborne allergens from dust mites, dogs, and cats using an ion-charging device. Clin Exp Allergy 2003;33(7):986–91. 10.1046/j.1365-2222.2003.01706.x
24 Grant TL, Wood RA, Chapman MD. Indoor environmental exposures and their relationship to allergic diseases. J Allergy Clin Immunol Pract 2023;11(10):2963–70. 10.1016/j.jaip.2023.08.034
25 Platts-Mills TAE. Allergy in evolution. Chem Immunol Allergy 2012;96:1–6. 10.1159/000331802
26 Paller AS, Spergel JM, Mina-Osorio P, Irvine AD. The atopic march and atopic multimorbidity: Many trajectories, many pathways. J Allergy Clin Immunol 2019;143(1):46–55. 10.1016/j.jaci.2018.11.006
27 Portnoy J, Miller JD, Williams PB, Chew GL, Miller JD, Zaitoun F, et al. Environmental assessment and exposure control of dust mites: A practice parameter. Ann Allergy Asthma Immunol 2013;111(6):465–507. 10.1016/j.anai.2013.09.018
28 Can Bostan O, Cakmak ME, Kaya SB, Tuncay G, Damadoglu E, Karakaya G, et al. The association of timothy grass allergy and cat ownership on cat sensitization. Allergy Asthma Proc 2022;43(3):220–5. 10.2500/aap.2022.43.220012
29 de Bot CM, Röder E, Pols DH, Bindels PJ, van Wijk RG, van der Wouden JC, et al. Sensitisation patterns and association with age, gender, and clinical symptoms in children with allergic rhinitis in primary care: A cross-sectional study. Prim Care Respir J 2013;22(2):155–60. 10.4104/pcrj.2013.00015
30 Gunaydin NC, Tanc C, Celiker ET, Kacmaz SG, Samanci N, Nalbantoglu A, et al. Aeroallergen sensitization in school-age children with allergic rhinitis: What has changed during the COVID-19 pandemic? Allergol Immunopathol (Madr) 2023;51(3):68–79. 10.15586/aei.v51i3.832
31 Zhang Y, Yan X, Shen X, Liu M, Zhou Y, He J, et al. Distribution characteristics and results of allergens in patients with allergic rhinitis in Ningxia area. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023;37(7):562–9.
