Drug-induced enterocolitis, a new condition under consideration

Main Article Content

Lucía Hernando Marín
Ana María Segura Machado
Marta Castro Ramos
Javier Torres-Borrego

Keywords

DIES (drug-induced enterocolitis syndrome), FPIES (food protein–induced enterocolitis syndrome), allergy, drugs, vomiting, diagnosis, pediatrics

Abstract

Drug-induced enterocolitis syndrome (DIES), little known due to its recent description, is analogous to food protein–induced enterocolitis syndrome (FPIES). Both processes are more frequent in pediatric age and share diagnostic criteria, the main one being the appearance of persistent vomiting 1–4 hours after ingestion of the drug or food, in the absence of IgE-mediated allergy symptoms.

Abstract 1053 | PDF Downloads 1124 HTML Downloads 0 XML Downloads 370

References

1 Kidon M, Blanca-Lopez N, Gomes E, Terreehorst I, Tanno L, Ponvert C, et al. EAACI/ENDA position paper: Diagnosis and management of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) in children and adolescents. PAI. 2018 Aug 13;29(5):469–80. 10.1111/pai.12915

2 Novembre E, Barni S, Saretta F, Castagnoli R, Arasi S, Mastrorilli C, et al. The history of the drug-induced enterocolitis syndrome. PAI. 2022 Jan 25;33(S27):54–7. 10.1111/pai.13630

3 Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, et al. International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & amp; Immunology. JACI. 2017 Apr;139(4):1111–1126.e4. 10.1016/j.jaci.2016.12.966

4 Mori F, Liccioli G, Fuchs O, Barni S, Giovannini M, Sarti L, et al. Drug-induced enterocolitis syndrome: Similarities and differences compared with food protein-induced enterocolitis syndrome. PAI. 2021 Aug 29;32(6):1165–72. 10.1111/pai.13491

5 Mori F, Liccioli G, Capone M, Giovannini M, Barni S, Sarti L, et al. T cell involvement in the pathogenesis of drug-induced enterocolitis syndrome. PAI. 2022 Feb 13;33(2). 10.1111/pai.13718

6 Berin MC, Lozano-Ojalvo D, Agashe C, Baker MG, Bird JA, Nowak-Wegrzyn A. Acute FPIES reactions are associated with an IL-17 inflammatory signature. JACI. 2021 Sep;148(3):895–901.e6. 10.1016/j.jaci.2021.04.012

7 Laiseca García j, Moreno Mata E, García Rodríguez C, González Muñoz M, Barrios Albajar M, Burgos Montero A, et al. Drug-induced enterocolitis syndrome with acetaminophen in an adult: A call for diagnostic tools and accurate management. JIACI. 2023 Dec 11;34(4). 10.18176/jiaci.0970

8 Entrala A, Domínguez-Ortega J, Pulido Lucas E, Losantos I, Lluch-Bernal M, Quirce S, et al. Lymphocyte transformation test in the diagnosis of adult fish-induced enterocolitis syndrome. J Allergy Clin Immunol Pract. 2023 Sep;11(9):2945–7. 10.1016/j.jaip.2023.06.013

9 Pichler WJ, Tilch J. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy. 2004 Aug;59(8):809–20. 10.1111/j.1398-9995.2004.00547.x

10 Pascal B, Evrard B, Merlin E, Egron C, Bonnet B, Michaud E. Drug-induced enterocolitis syndrome with paracetamol (acetaminophen) in a 12-month-old boy. PAI. 2022 Mar 3;33(3): e13755. 10.1111/pai.13755