Efficacy of Xuanbai Chengqi decoction combined with western medicine in treating AECOPD with phlegm-heat obstructing lung syndrome: a clinical study

Main Article Content

Quan He
Guangfei Wei
Xuzhi Lu
Weiqi Feng
Meiyue Yu
Xiaomei Ma

Keywords

AECOPD, clinical efficacy, phlegm-heat obstructing lung syndrome, Xuanbai Chengqi decoction

Abstract

Objective: To explore the efficacy of Xuanbai Chengqi Decoction combined with conventional Western medicine in the treatment of AECOPD patients with phlegm-heat obstructing the lung syndrome.


Methods: A retrospective analysis was conducted on the clinical data of 166 patients with this syndrome admitted to our hospital between December 2023 and March 2024. Patients were divided into a study group (Xuanbai Chengqi Decoction + conventional Western medicine treatment, 83 cases) and a control group (conventional Western medicine treatment, 83 cases). The clinical efficacy, Traditional Chinese Medicine (TCM) syndrome scores, blood routine indicators, inflammatory factors, and other clinical outcomes were compared between the two groups.


Results: Before treatment, there were no significant differences in the above-mentioned indicators between the two groups (P > 0.05). After treatment, the study group showed a significantly higher overall effective treatment rate, lymphocyte percentage, SOD, and NO levels, and a significantly lower TCM syndrome score, neutrophil percentage, white blood cell count, TNF-α, IL-6, CRP, and MOD levels, with statistical significance (P < 0.05).


Conclusion: Xuanbai Chengqi Decoction combined with Western medicine treatment can effectively alleviate the clinical symptoms of AECOPD patients with phlegm-heat obstructing the lungs syndrome, improve blood routine indicators, control inflammation, and enhance the overall therapeutic effect.

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References

1 Liu X et al., Prevalence, risk factor and clinical characteristics of venous thrombus embolism in patients with acute exacerbation of COPD: A prospective multicenter study. Int J Chron Obstruct Pulmon Dis. 2023;18:907–917. 10.2147/COPD.S410954

2 Hoult G, Gillespie D, Wilkinson TMA., Thomas M Francis NA. Biomarkers to guide the use of antibiotics for acute exacerbations of COPD (AECOPD): A systematic review and meta-analysis. BMC Pulmon Med. 2022;22(1):194. 10.1186/s12890-022-01958-4

3 Wu C-T et al. Acute exacerbation of a chronic obstructive pulmonary disease prediction system using wearable device data, machine learning, and deep learning: development and cohort study. JMIR mHealth uHealth. 2021;9(5):e22591. 10.2196/22591

4 Vermeersch K et al. Azithromycin during acute chronic obstructive pulmonary disease exacerbations requiring hospitalization (BACE). A multicenter, randomized, double-blind, placebo-controlled trial. Am J Resp Crit Care Med. 2019;200(7):857–868. 10.1164/rccm.201901-0094OC

5 Cazzola M, Rogliani P, Ora J, Calzetta L, Lauro D, Matera MG. Hyperglycaemia and chronic obstructive pulmonary disease. Diagnostics (Basel, Switzerland). 2023;13(21):3362. 10.3390/diagnostics13213362

6 Cao X et al. Advances in traditional Chinese medicine for the treatment of chronic obstructive pulmonary disease. J Ethnopharmacol. 2023;307:116229. 10.1016/j.jep.2023.116229

7 Jiao J et al. The therapeutic effect of Xuanbai Chengqi decoction on chronic obstructive pulmonary disease with excessive heat in the lung and FU-organs based on gut and lung microbiota as well as metabolic profiles. J Chromatogr B Analyt Technol Biomed Life Sci. 2022;1198:123250. 10.1016/j.jchromb.2022.123250

8 Liu D, Zou Y, Wang Y, Investigation on the relationship between sleep quality and depression and anxiety in hospitalized patients with different levels of AECOPD. Comp Math Methods Med. 2022;2022:5901552. 10.1155/2022/5901552

9 Büyükbayram G, Yüceer Ö., Oymak FS. The relationship between serum uric acid levels and early mortality in chronic obstructive pulmonary disease cases during exacerbation. Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(2):e2022014. 10.36141/svdld.v39i2.12127

10 Sandelowsky H et al. COPD—Do the right thing. BMC Fam Pract. 2021;22(1):244. 10.1186/s12875-021-01583-w

11 Shang B et al. Insights from the perspective of traditional Chinese medicine to elucidate association of lily disease and yin deficiency and internal heat of depression. Evid Based Complement Alternat Med (eCAM). 2020;2020:8899079. 10.1155/2020/8899079

12 Pratt AJ et al. Complexity in clinical diagnoses of acute exacerbation of chronic obstructive pulmonary disease. BMC Pulmon Med. 2023;23(1):298. 10.1186/s12890-023-02587-1

13 Sim YS, Lee JH, Lee EG, Choi JY, Lee CH, An TJ, et al. COPD exacerbation-related pathogens and previous COPD treatment. J Clin Med. 2022;12(1):111. 10.3390/jcm12010111

14 Qi R et al. The efficacy and safety of Xinjia Xuanbai Chengqi granules in acute exacerbation of COPD: A multicentre, randomised, double-blind, controlled trial. Evid Based Complement Alternat Med (eCAM). 2022;2022:7366320. 10.1155/2022/7366320

15 Jin J et al. Effectiveness of Xin Jia Xuan Bai Cheng Qi decoction in treating acute exacerbation of chronic obstructive pulmonary disease: Study protocol for a multicentre, randomised, controlled trial. BMJ Open. 2019;9(11):e030249. 10.1136/bmjopen-2019-030249

16 Niu Y et al. Effect of community-acquired pneumonia on acute exacerbation of chronic obstructive pulmonary disease. COPD. 2021;18(4):417–424. 10.1080/15412555.2021.1950664

17 Liu M, Hu R, Jiang X, Mei X. Coagulation dysfunction in patients with AECOPD and its relation to infection and hypercapnia. J Clin Lab Anal. 2021;35(4):e23733. 10.1002/jcla.23733

18 Tao L et al. Tong Sai granule improves AECOPD via regulation of MAPK-SIRT1-NF-κB pathway and cellular senescence alleviation. J Ethnopharmacol. 2023;314:116622. 10.1016/j.jep.2023.116622

19 Singh B, Kampani G, Lall B, Singh M. Study of inflammatory markers in chronic obstructive pulmonary disease. J Assoc Physicians India (JAPI). 2022;70(12):11–12. 10.5005/japi-11001-016

20 Di J, Li X, Xie Y, Yang S, Yu X. Procalcitonin-guided antibiotic therapy in AECOPD patients: Overview of systematic reviews. Clin Resp J. 2021;15(6):579–594. 10.1111/crj.13345

21 Chen X, Kang F, Lai J, Deng X, Guo X, Liu S. Comparative effectiveness of phlegm-heat clearing Chinese medicine injections for AECOPD: A systematic review and network meta-analysis. J Ethnopharmacol. 2022;292:115043. 10.1016/j.jep.2022.115043

22 Fernández-Jané C, Vilaró J. Acupoint transcutaneous electrical nerve stimulation in hospitalized COPD patients with severe dyspnoea: Study protocol for a randomized controlled trial. Trials. 2019;20(1):707. 10.1186/s13063-019-3757-x

23 Shao S, Zhang Z, Feng L, Liang L, Tong Z. Association of blood inflammatory biomarkers with clinical outcomes in patients with AECOPD: An 8-year retrospective study in Beijing. Int J Chron Obstruct Pulmon Dis. 2023;18:1783–1802. 10.2147/COPD.S416869