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asthma, allergic rhinitis, eczema, ISAAC prevalence
Aim: The authors conducted two cross-sectional studies 8 years apart with the aim of assessing temporal trends in the prevalence of asthma and atopic diseases in Međimurje County, Northwestern Croatia.
Methods: Studies were conducted in children aged 12 years 0 months to 14 years 11 months in 2005 and in 2013; additionally, in adolescents aged 18 years in 2013 according to the international study on asthma and allergies protocol.
Results: In the age group 12–14 years, a significant increase in the prevalence of asthma (5.1% vs 8.31%), allergic rhinitis (10.86% vs 16.24%), allergic rhinoconjunctivitis (7.14% vs 10.95%) and atopic dermatitis (5.34% vs 8.12%) was observed. When the age group 12–14 years in 2005 was compared with the age group 18 years in 2013, a significant increase in symptoms of asthma (5.1% vs 11.5%), allergic rhinitis (10.86% vs 19.59%), allergic rhinoconjunctivitis (7.14% vs 14.25%), and atopic dermatitis (5.34% vs 7.69%) was observed.
Conclusion: This study shows an increasing trend in Međimurje County in the prevalence of all symptoms associated with atopic diseases: Asthma, allergic rhinitis, allergic rhinoconjunctivitis, and atopic dermatitis.
2. Bjorksten B, Clayton T, Ellwood P, Stewart A, Strachan D, ISAAC Phase III Study Group. Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol. 2008;19(2):110–124. https://doi.org/10.1111/j.1399-3038.2007.00601.x
3. Munivrana H, Vorko-Jovic A, Munivrana S, Kursar M, Medlobi-Gluhak M, Vlahek P. The prevalence of allergic diseases among Croatian school children according to the ISAAC Phase One questionnaire. Med Sci Monit. 2007;13(1):505–509.
4 . Drkulec V, Tesari H, Tomic-Rajic M, Navratil M, Plavec D., Nogalo B. et al. The prevalence of asthma, allergic rhinitis/rhinoconjunctivitis and atopic eczema among Croatian school children in Pozesko-Slavonska County (ISAAC phase I). In: Stipic-Marković A, Cvoriscec B, editors. Proceedings of the 1st Croatian Congress of Allergollogy and Clinical Immunology. 2009 May 21–23; Zagreb, Croatia. p. 19.
5. Stipic-Markovic A, Cvoriscec B, Pevec B, Radulovic-Pevec M. Increasing incidence of allergy in Croatia. Rad Med Sci Zagreb. 2008;499:105–116.
6. Stipic-Markovic A, Pevec B, Radulovic-Pevec M, Custovic A. Prevalence of symptoms of asthma, allergic rhinitis, conjunctivitis and atopic eczema: ISAAC in a population of school children in Zagreb [in Croatian]. Acta Med Croatica. 2003;57:281–285.
7. Banac S, Lah-Tomulić K, Ahel V, Rozmanić V, Simundić N, Zubović S, et al. Prevalence of asthma and allergic diseases in Croatian children is increasing: Survey study. Croat Med J. 2004;45:721–726.
8. Banac S, Rozmanic V, Manestar K, Korotaj-Rozmanic Z, Lah-TomulicK, Vidovic I, et al. Rising trends in the prevalence of asthma and allergic diseases among school children in the north-west coastal part of Croatia. J Asthma. 2013;50(8):810–814. https://doi.org/10.3109/02770903.2013.803115
9. Aberle N, Kljaić Bukvić B, Blekić M, Vučković M, Bardak D, Gudelj A, et al. Allergic diseases and atopy among schoolchildren in Eastern Croatia. Acta Clin Croatica. 2018;57(1):82–90. https://doi.org/10.20471/acc.2018.57.01.09
10. Gudelj I, Mrkić Kobal I, Munivrana Škvorc H, Miše K, Vrbica Z, Plavec D, et al. Intraregional differences in asthma prevalence and risk factors for asthma among adolescents in Split-Dalmatia County, Croatia. Med Sci Monit. 2012:18(4):43–50. https://doi.org/10.12659/MSM.882609
11. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. International Study of Asthma and Allergies in Childhood (ISAAC): Rationale and methods. Eur Respir J. 1995;8(3):483–491. https://doi.org/10.1183/09031936.95.08030483
12. Weiland SK, Beasley R, Strachan D. Guidelines for the translation of questionnaires. Münster, Germany: ISAAC Phase One Coordinating Committee; 1993.
13. Kuzman M, Pejnovi ć Franelić I, Pavi ć Š imetin I, Pejak M. European school survey project on alcohol and other drugs: Report for Republic of Croatia and the city of Zagreb. Zagreb: Hrvatski zavod za javno zdravstvo, Grad Zagreb; 2008. Change in habits among students in period 1995–2007. p. 43.
14. Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, et al. Worldwide trends in the prevalence of asthma symptoms: Phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2007;62(9):758–766. https://doi.org/10.1136/thx.2006.070169
15. Dharmage SC, Perret JL, Custovic A. Epidemiology of asthma in children and adults. Front Pediatr. 2019;7:2296–2360. https://doi.org/10.3389/fped.2019.00246
16. Kuruvilla ME, Vanijcharoenkarn K, Shih JA, Lee FEH. Epidemiology and risk factors for asthma. Respir Med. 2019;149:16–22. https://doi.org/10.1016/j.rmed.2019.01.014
17. Munivrana Škvorc H. Risk factors for atopy diseases in schoolchildren. PhD thesis; 2014 -. Faculty of Medicine, University of Zagreb, http: medlib.mef.hr/2130
18. Bjorksten B, Clayton T, Ellwood P, Stewart A, Strachan D, The ISAAC Phase III Study Group. Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol. 2008;19(2):110–124. https://doi.org/10.1111/j.1399-3038.2007.00601.x
19. Maziak W, Behrens T, Brasky TM, Duhme H, Rzehak P, Weiland SK, et al. Are asthma and allergies in children and adolescents increasing? Results from ISAAC phase I and phase III surveys in Munster, Germany. Allergy. 2003;58(7):572–579. https://doi.org/10.1034/j.1398-9995.2003.00161.x
20. Munivrana Skvorc H, Plavec D, Munivrana S, Skvorc M, Nogalo B, Turkalj M. Prevalence of and risk factors for the development of atopic dermatitis in schoolchildren aged 12–14 in northwest Croatia. Allergologia Et Immunopathologia. 2014;42(2):142–148. https://doi.org/10.1016/j.aller.2012.10.008
21. Haidinger G, Waldhor T, Meusburger S, Suss G, Vutuc C. The prevalence of childhood asthma and of allergies in 7 districts of Upper Austria—ISAAC III. Allergologie. 2008;31:17–22. https://doi.org/10.5414/ALP31017
22. Frohlich M, Pinart M, Keller T, Reich A, Cabieses B, Hohmann C, et al. Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis. Clin Transl Allergy. 2017;7:9. https://doi.org/10.1186/s13601-017-0176-5
23. Ferrante G, La Grutta S. The burden of pediatric asthma. Front Pediatr. 2018;6:7. https://doi.org/10.3389/fped.2018.00186
24. Zein JG, Erzurum SC. Asthma is different in women. Curr Allergy Asthma Rep. 2015;15:10. https://doi.org/10.1007/s11882-015-0528-y
25. Kalm-Stephens P, Nordvall L, Janson C, Neuman A, Malinovschi A, Alving K. Different baseline characteristics are associated with incident wheeze in female and male adolescents. Acta Paediatr. 2020;109(11):2324–2331. https://doi.org/10.1111/apa.15263
26. Pinart M, Keller T, Reich A, Frohlich M, Cabieses B, Hohmann C, et al. Sex-related allergic rhinitis prevalence switch from childhood to adulthood: A systematic review and meta-analysis. Int Arch Allergy Immunol. 2017;172(4):224–235. https://doi.org/10.1159/000464324