Evolution of laboratory parameters in patients with lipid transfer protein syndrome after 3 years of immunotherapy

Main Article Content

Alejandra González Pérez
Ana Isabel Escudero Pastor
Rosa Alba Sola Martínez
Antonio Carbonell Martínez


allergic reaction, anaphylaxis, food tolerance, immune tolerance, immunotherapy, lipid transfer proteins, LTP syndrome, Pru p 3


Lipid transfer protein (LTP) syndrome is an increasingly prevailing disease, especially in the young population, with severely affected quality of life. Since 2013, a specific treatment, called sublingual immunotherapy (SLIT), with peach extract (SLIT-peach®) has been used, but with no long-term effectiveness studies. The main objective of the present study was to assess the long-term effectiveness of SLIT-peach® and to relate the clinical evolution of patients. This was an ambispective study conducted for 3 years. A total of 25 patients with LTP syndrome were selected and treated with SLIT-peach®. They underwent a provocation test in the first year with reintroduced foods that had produced symptoms in the past. Analytical determination of specific immunoglobulin E (IgE) and immunoglobulin G4 (IgG4) to peach (Pru p 3) was performed at the beginning of treatment, at the first year of initiation, and at the end of treatment. These data were compared with the control group comprising 14 patients with LTP syndrome without treatment. A statistically significant decrease in specific IgE to Pru p 3 at the end of the treatment and an increase in specific IgG4 to Pru p 3 1 year after treatment initiation were observed in the active group in relation to tolerance to foods with LTPs. These results indicate that food tolerance begins after the first year and is maintained after the end of 3 years of treatment. In conclusion, treatment with SLIT-peach® for 3 years is effective for patients with LTP syndrome, preventing the evolution of the disease, allowing patients to restart a diet with plant foods, and improving their quality of life.

Abstract 440 | PDF Downloads 436 HTML Downloads 40 XML Downloads 21


1. Van Ree R. Clinical importance of non-specific lipid transfer proteins as food allergens. Biochem Soc Trans. 2002 Nov;30(Pt 6):910–3. 10.1042/bst0300910

2. Chapman M. Allergen nomenclature. In: Lockey RF BS, editors. Allergens and allergen immunotherapy. Marcel Dekker Inc. New York, NY; 1999. pp. 73–83.

3. Asero R, Mistrello G, Roncarolo D, Amato S, Caldironi G, Barocci F, et al. Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: A clinical study. Allergy. 2002 Oct;57(10):900–6. 10.1034/j.1398-9995.2002.t01-1-23541.x

4. González Pérez A, Carbonell Martínez A, Escudero Pastor AI, Navarro Garrido C, Miralles López JC. Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome. Clin Transl Allergy. 2020 Jun 8;10(1): 10.1186/s13601-020-00325-y

5. Sugimoto M, Kamemura N, Nagao M, Irahara M, Kagami S, Fujisawa T, et al. Differential response in allergen-specific IgE, IgGs, and IgA levels for predicting outcome of oral immunotherapy. Pediatr Allergy Immunol. 2016 May 1;27(3):276–82. 10.1111/pai.12535