Severity of disease and the quality of life indexes in infants with atopic dermatitis

Main Article Content

Seda Şirin Köse
Zülfikar Akelma
Serap Özmen

Keywords

Atopic dermatitis, disease severity, infants, quality of life indexes, sleep disturbance score

Abstract

Background: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease. In this study, the relationship between the severity of AD and the quality of life (QoL) of patients and their families were evaluated; also, the factors that predict the severity of AD and the QoL index were determined.


Methods: Infants with AD were enrolled in the study. Pruritus, sleep disturbance, and dermatitis severity scores were obtained. The QoL of infants was assessed using the Infants’ Dermatitis Quality of Life Index (IDQOL), while the Family Dermatology Life Quality Index (FDLQI) was used to assess the impact of disease on the QoL of parents.


Results: 122 patients diagnosed with AD were enrolled in the study. The correlation analysis of score showed a positive correlation between IDQOL and FDLQI (r = 0.444, p < 0.0001). Positive correlations between the pruritus, sleep disturbance, Severity Scoring of Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and dermatitis severity scores and the QoL indexes were found. While pruritus, sleep disturbance scores, and EASI were the most significant parameters for predicting a severe SCORAD score, IDOQL, FDLQI, and SCORAD were the most significant parameters for predicting severe EASI. In the analysis of QoL indexes, sleep disturbance and FDLQI were the most significant parameters for predicting severe IDQOL index, while IDQOL was the most significant parameter for predicting severe FDLQI scores.


Conclusions: AD has a negative effect on the QoL of infants and their parents. Pruritus and sleep disturbance should be evaluated during clinical practice due to their strong relationship with disease severity and QoL index.

Abstract 118 | PDF Downloads 91 HTML Downloads 46 XML Downloads 4

References

1. Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Prim. 2018;4(1):1. 10.1038/s41572-018-0001-z

2. Hanifin JM, Rajka G. Diagnostic features of atopic-dermatitis. Acta Derm Venereol. 1980; 92:44–47.

3. Oranje AP, Glazenburg EJ, Wolkerstorfer A, de Waard-van der Spek FB. Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three-item severity score. Br J Dermatol. 2007;157(4):645–8. 10.1111/j.1365-2133.2007.08112.x

4. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993;186(1):23–31. 10.1159/000247298

5. Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp Dermatol. 2001;10(1):11–18. 10.1034/j.1600-0625.2001.100102.x

6. Marciniak J, Reich A, Szepietowski JC. Quality of life of parents of children with atopic dermatitis. Acta Derm Venereol. 2017;97(6):711–14. 10.2340/00015555-2633

7. Chernyshov PV. Gender differences in health-related and family quality of life in young children with atopic dermatitis. Int J Dermatol. 2012;51(3):290–4. 10.1111/j.1365-4632.2011.04997.x

8. Monti F, Agostini F, Gobbi F, Neri E, Schianchi S, Arcangeli F. Quality of life measures in Italian children with atopic dermatitis and their families. Ital J Pediatr. 2011;37:59. 10.1186/1824-7288-37-59

9. Eiser C, Morse R. The measurement of quality of life in children: past and future perspectives. J Dev Behav Pediatr. 2001; 22(4):248–56. 10.1097/00004703-200108000-00007

10. Djurović MR, Janković J, Ćirković A, Spirić VT, Maksimović N, Timotijević ZS, et al. Quality of life in infants with atopic dermatitis and their families. Postepy Dermatol Alergol. 2020;37(1):66–72. 10.5114/ada.2020.93385

11. Siafaka V, Zioga A, Evrenoglou T, Mavridis D, Tsabouri S. Illness perceptions and quality of life in families with child with atopic dermatitis. Allergol Immunopathol (Madr). 2020;48(6):603–11. 10.1016/j.aller.2020.03.003

12. Sajedianfard S, Handjani F, Saki N, Heiran A. Family dermatology life quality index in patients with pemphigus vulgaris: a cross-sectional study. Indian J Dermatol Venereol Leprol. 2021;87(3):375–8. 10.4103/ijdvl.IJDVL_276_18

13. Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? J Invest Dermatol. 2005;125(4):659–64. 10.1111/j.0022-202X.2005.23621.x

14. Kim DH, Li K, Seo SJ, Jo SJ, Yim HW, Kim CM, et al. Quality of life and disease severity are correlated in patients with atopic dermatitis. J Korean Med Sci. 2012;27(11):1327–32. 10.3346/jkms.2012.27.11.1327

15. Çömlek F, Toprak A, Nursoy MA. Assessment of dermatological quality of life in patients with childhood atopic dermatitis and their families. Turk Pediatri Ars. 2020;55(3):270–6.

16. Ramirez FD, Chen S, Langan SM, Prather AA, McCulloch CE, Kidd SA, et al. Association of atopic dermatitis with sleep quality in children. JAMA Pediatr. 2019;173(5):e190025. 10.1001/jamapediatrics.2019.0025

17. Xu X, van Galen LS, Koh MJA, Bajpai R, Thng S, Yew YW, et al. Factors influencing quality of life in children with atopic dermatitis and their caregivers: a cross-sectional study. Sci Rep. 2019;9(1):15990. 10.1038/s41598-019-51129-5

18. Alexopoulos A, Kakourou T, Orfanou I, Xaidara A, Chrousos G. Retrospective analysis of the relationship between infantile seborrheic dermatitis and atopic dermatitis. Pediatr Dermatol. 2014;31(2):125–30. 10.1111/pde.12216