Prevalence of inhaled allergen sensitization among patients with suspected allergic diseases in Sichuan province: 3-year data from a single center
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Keywords
Allergen, Allergen spectrum, Allergic disease, sIgE, tIgE
Abstract
Allergic diseases are becoming increasingly common, and they are a threat to people’s health. Exploring the distribution characteristics of allergen-specific immunoglobulin E (sIgE) in people from Sichuan province, southwest China, can provide clinical epidemiological data. This study enrolled 12,204 consecutive patients with suspected allergies from May 2018 to May 2021. Among the patients, 4206 were diagnosed with allergic rhinitis or asthma. The Rayto Lumiray 1600 detection system and sIgE and total IgE (tIgE) detection kits were used to measure the levels of nine common sIgE and tIgE. sIgE ≥ 0.35 IU/mL was considered positive. The sensitization rate of D1 (Dermatophagoides pteronyssinus) is the highest (22.97%), followed by D2 (Dermatophagoides farinae) (23.33%); M3 (Aspergillus fumigatus) has the lowest positive rate (1.5%). E5 (Canis familiaris) and I6 (Blatella germanica) exhibited relatively high sensitization rates (8.64% and 12.35%, respectively). Allergen sensitization was significantly higher in men than in women. Moreover, 90.3% of sensitization samples from D1 were combined with at least one of the other eight allergens. Similarly, a positive correlation was demonstrated between D1, D2, and E1 (Felis domesticus). In addition, patients with allergic rhinitis (91.88% and 91.54%, respectively), allergic asthma (72.44% and 74.01%, respectively), and allergic rhinitis with asthma (92.12% and 93.22%, respectively) were mainly sensitized to D1 and D2. D1, D2, I6, and E5 are the main allergens. Moreover, D1 and D2 are the main allergens in patients with respiratory allergic diseases. Research focusing on the distribution of allergens and the characteristics of hypersensitivity in different people helps prevent, diagnose, and treat allergic diseases.
References
2 Tham EH, Lee AJ, Bever HV. Aeroallergen sensitization and allergic disease phenotypes in Asia. Asian Pac J Allergy Immunol. 2016; 34(3):181–189.
3 O’Hehir RE. Immunology and allergy. MJA. 2002;176(1):22. 10.5694/j.1326-5377.2002.tb04255.x
4 Sanz ML. Legends of allergy/immunology: Albert K. Oehling. Allergy. 2019;74(2):382–384. 10.1111/all.13601
5 Foley SC, Préfontaine D, Hamid Q. Images in allergy and immunology: role of eosinophils in airway remodeling. J Allergy Clin Immunol. 2007; 119(6):1563–6. 10.1016/j.jaci.2007.03.040
6 Su N, et al. An epidemiological survey on management and insights of asthma in China in 2009 to 2010. Zhonghua nei ke za zhi. 2015;54(8): 680–683.
7 Zhang L, et al. Prevalence of self-reported allergic rhinitis in eleven major cities in China. Int Arch Allergy Appl Immunol. 2009;149(1):47–57. 10.1159/000176306
8 Platts-Mills TAE, et al. IgE in the diagnosis and treatment of allergic disease. JACI. 2016;137(6):1662–1670. 10.1016/j.jaci.2016.04.010
9 de Vos G. Skin testing versus serum-specific IgE testing: which is better for diagnosing aeroallergen sensitization and predicting clinical allergy? Curr Allergy Asthma Rep. 2014;14(5):430. 10.1007/s11882-014-0430-z
10 Zeng G, et al. A cross-sectional observational study on allergen-specific IgE positivity in a southeast coastal versus a southwest inland region of China. Sci Rep. 2017;7(1):9593. 10.1038/s41598-017-10109-3
11 Rabe KF, et al. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. JACI. 2004;114(1):40–47. 10.1016/j.jaci.2004.04.042
12 Coutinho V, et al. Interference of cross-reactive carbohydrates in the determination of specific IgE in alcohol drinkers and strategies to minimize it: the example of latex. Ann Allergy Asthma Immunol. 2008; 101(4):394–401. 10.1016/S1081-1206(10)60316-X
13 Hamilton RG, et al. Advances in IgE testing for diagnosis of allergic disease. J Allergy Clin Immunol Pract. 2020. 8(8): 2495–2504. 10.1016/j.jaip.2020.07.021
14 Vidal C, et al. Immunoglobulin-E reactivity to a glycosylated food allergen (peanuts) due to interference with cross-reactive carbohydrate determinants in heavy drinkers. Alcohol Clin Exp Res. 2009;33(8): 1322–8. 10.1111/j.1530-0277.2009.00961.x
15 Wang J, Godbold JH, Sampson HA. Correlation of serum allergy (IgE) tests performed by different assay systems. JACI. 2008;121(5):1219–1224. 10.1016/j.jaci.2007.12.1150
16 Erratum Figure Correction: Aeroallergen sensitization and allergic disease phenotypes in Asia. Asian Pac J Allergy Immunol. 2017;35(1): 66.
17 Longo G, et al. IgE-mediated food allergy in children. Lancet. 2013; 382(9905):1656–64. 10.1016/S0140-6736(13)60309-8
18 Quintero-Campos P, et al. Multiparametric highly sensitive chemiluminescence immunoassay for quantification of β-Lactam-specific immunoglobulin E. Anal Chem. 2020;92(21): 14608–14615. 10.1021/acs.analchem.0c03020
19 Wang Q, Liu ZG, Ji KM. [Detection of Periplaneta americana sIgE with chemiluminescent immunoassay (CLIA)]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006;24(6):471–2.
20 Lou H, et al. Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China. Sci Rep. 2017; 7(1): 9286. 10.1038/s41598-017-10111-9
21 Sun X, et al. Prevalence of allergen sensitization among 15,534 patients with suspected allergic diseases in Henan Province, China. Asian Pac J Allergy Immunol. 2019;37(2):57–64.
22 Liao C, et al. Shrimp and cockroach co-sensitization in Southern China: association with moth sensitization. Allergy Asthma Proc. 2020;41(3): e54–e60. 10.2500/aap.2020.41.200013
23 Zheng YW, et al. Indoor allergen levels and household distributions in nine cities across China. Biomed Environ Sci. 2015;28(10):709–17.
24 Ciprandi G, et al. Serum allergen-specific IgE, allergic rhinitis severity, and age. Rhinology. 2016;54(3):231–8. 10.4193/Rhin15.300
25 Nagasaki T, et al. Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation. Clin Exp Allergy. 2013; 43(6):608–15. 10.1111/cea.12073
26 Paula Couto TA, et al. Total IgE plasma levels vary according to gender and age in Brazilian patients with allergic rhinitis. Clinics (Sao Paulo). 2014;69(11):740–4. 10.6061/clinics/2014(11)06
27 Cassano N, et al. Gender-related differences in chronic urticaria. G Ital Dermatol Venereol. 2016;151(5):544–52.
28 Panzner P, et al. Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region. CTA. 2018;8:19. 10.1186/s13601-018-0207-x
29 Hu H, et al. A pilot study on the allergen-specific IgE to molecular components on polysensitized mite allergic asthmatic patients in Guangzhou, China. Mol Immunol. 2019;105:38–45. 10.1016/j.molimm.2018.11.004
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