Inhaled corticosteroids may have a protective effect against coronavirus infection

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Alicia Armentia
Sara Fernández Cortés
Angela Moro Simón
Blanca Martín-Armentia
Sara Martín-Armentia
Daniel Ramos Pollo
Juan Claudio Navarro Cañadas
Javier Visa Caño
Álvaro Sanz Rubiales
Joaquín Rodriguez Fra
Sara García Vaquero
Marta Cano Pazos
Jesús Galán de la Calle
Edgardo Raul Lowell
Cristina Crespo Soto
Carmen Sánchez Toledano
Aurora Sacristán Salgado

Keywords

Allergy, coronavirus, nursing home, asthma severe, corticosteroids, COVID, telemedicine., Th2 cell immunity, coronavirus infection

Abstract

Background: Spain has been severely affected by the COVID-19 epidemic, with 195,944 persons infected and 20,453 deaths at the time of writing. Older people with respiratory or cardiac conditions are most at risk.


Objective: The aim was to compare respiratory symptoms in nursing home residents and patients with uncontrolled asthma, who are considered vulnerable to COVID-19.


Methods: We studied 134 nursing home residents and 139 patients with uncontrolled asthma, groups vulnerable to COVID-19. Demographic characteristics, clinical manifestations, outcomes, key laboratory results, and radiological images were collected from medical records. COVID-19 infection was detected by polymerase chain reaction (PCR).


Results: Thirteen (9.3%) patients with uncontrolled asthma, all receiving inhaled corticosteroids were infected by COVID-19. Eighty (60%) nursing home residents were infected; only 28, all of whom had received inhaled corticosteroids, had a good prognosis.


Conclusions: Early treatment with inhaled corticosteroids may be helpful in COVID-19 infection. Persons with an allergy might have some protective mechanisms against coronavirus.

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