Unveiling the hidden power of noncoding RNAs in pediatric respiratory diseases
Main Article Content
Keywords
biomarker, noncoding RNAs, pediatric respiratory diseases, respiratory system
Abstract
Respiratory diseases in children are common health problems that significantly impact their quality of life and health status, and this has its own unique challenges compared to adults. A growing body of research has focused on epigenetic mechanisms that relate with the development of various diseases, such as pediatric respiratory diseases. Noncoding RNAs (ncRNAs), especially long noncoding RNAs, microRNA, and circular RNA, are reported to play a regulatory role in pediatric respiratory diseases whose mutations or aberrant expressions are strongly associated with the development of these diseases. In this review, we mainly discussed the functions of these three ncRNAs in pediatric respiratory diseases.
References
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2 Cech TR, Steitz JA. The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 2014;157:77–94. 10.1016/j.cell.2014.03.008
3 Zhang M, Han Y. MicroRNAs in chronic pediatric diseases (review). Exp Ther Med. 2024;27:100. 10.3892/etm.2024.12388
4 Safi A, Saberiyan M, Sanaei MJ, Adelian S, Davarani Asl F, Zeinaly M, et al. The role of noncoding RNAs in metabolic reprogramming of cancer cells. Cell Mol Biol Lett. 2023;28:37. 10.1186/s11658-023-00447-8
5 Zhang P, Wu W, Chen Q, Chen M. Noncoding RNAs and their integrated networks. J Integr Bioinform. 2019;16(3):20190027. 10.1515/jib-2019-0027
6 Dayal S, Chaubey D, Joshi DC, Ranmale S, Pillai B. Noncoding RNAs: Emerging regulators of behavioral complexity. Wiley Interdiscip Rev RNA. 2024;15:e1847. 10.1002/wrna.1847
7 Sonego M, Pellegrin MC, Becker G, Lazzerini M. Risk factors for mortality from acute lower respiratory infections (ALRI) in children under five years of age in low-and middle-income countries: A systematic review and meta-analysis of observational studies. PloS One. 2015;10:e0116380. 10.1371/journal.pone.0116380
8 Brennan LC, O’Sullivan A, MacLoughlin R. Cellular therapy for the treatment of paediatric respiratory disease. Int J Mol Sci. 2021;22(16):8906. 10.3390/ijms22168906
9 GBD Chronic Respiratory Disease Collaborators. Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Resp Med. 2020;8:585–96. 10.1016/S2213-2600(20)30105-3
10 Scotet V, L’Hostis C, Férec C. The changing epidemiology of cystic fibrosis: Incidence, survival and impact of the CFTR gene discovery. Genes (Basel). 2020;11(6):589. 10.3390/genes11060589
11 Lambrecht BN, Hammad H. The immunology of asthma. Nat Immunol. 2015;16:45–56. 10.1038/ni.3049
12 Lin R, Guan R, Liu X, Zhao B, Guan J, Lu L. Significant rise of the prevalence and clinical features of childhood asthma in Qingdao China: Cluster sampling investigation of 10,082 children. BMC Public Health. 2014;14:1002. 10.1186/1471-2458-14-1002
13 Haktanir Abul M, Phipatanakul W. Severe asthma in children: Evaluation and management. Allergol Int. 2019;68:150–7. 10.1016/j.alit.2018.11.007
14 Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141:1202–7. 10.1016/j.jaci.2017.08.034
15 Kho AT, McGeachie MJ, Moore KG, Sylvia JM, Weiss ST, Tantisira KG. Circulating microRNAs and prediction of asthma exacerbation in childhood asthma. Resp Res. 2018;19:128. 10.1186/s12931-018-0828-6
16 Tiwari A, Hobbs BD, Li J, Kho AT, Amr S, Celedón JC, et al. Blood miRNAs are linked to frequent asthma exacerbations in childhood asthma and adult COPD. Noncoding RNA. 2022;8(2):27. 10.3390/ncrna8020027
17 Mendez KM, Begum S, Tiwari A, Sharma R, Chen Q, Kelly RS, et al. Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma. EBioMedicine. 2024;102:105025. 10.1016/j.ebiom.2024.105025
18 Polikepahad S, Knight JM, Naghavi AO, Oplt T, Creighton CJ, Shaw C, et al. Proinflammatory role for LET-7 microRNAS in experimental asthma. J Biol Chem. 2010;285:30139–49. 10.1074/jbc.M110.14569810.1074/jbc.N110.145698
19 Sawant DV, Yao W, Wright Z, Sawyers C, Tepper RS, Gupta SK, et al. Serum MicroRNA-21 as a biomarker for allergic inflammatory disease in children. MicroRNA (Shariqah, UAE). 2015;4:36–40. 10.2174/2211536604666150220232507
20 Chiba Y. Noncoding RNAs and bronchial smooth muscle hyperresponsiveness in allergic bronchial asthma. Nihon Yakurigaku Zasshi Folia Pharmacol Japonica. 2020;155:364–8. 10.1254/fpj.20053
21 Mohamed JS, Lopez MA, Boriek AM. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β. J Biol Chem. 2010;285:29336–47. 10.1074/jbc.M110.101147
22 Hu R, Pan W, Fedulov AV, Jester W, Jones MR, Weiss ST, et al. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J. 2014;28:2347–57. 10.1096/fj.13-247247
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Nov 1, 2024
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Yu, S., Chen, L., Zhang, M., & Lu, Y. (2024). Unveiling the hidden power of noncoding RNAs in pediatric respiratory diseases. Allergologia Et Immunopathologia, 52(6), 128-136. https://doi.org/10.15586/aei.v52i6.1127
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How to Cite
Yu, S., Chen, L., Zhang, M., & Lu, Y. (2024). Unveiling the hidden power of noncoding RNAs in pediatric respiratory diseases. Allergologia Et Immunopathologia, 52(6), 128-136. https://doi.org/10.15586/aei.v52i6.1127