Consequence of COVID-19 on allergic asthma outcomes: a systematic review and meta-analysis
Main Article Content
Keywords
COVID-19, Allergy, Asthma, SARS-Cov2, Risk
Abstract
Asthma is a common chronic lung disease, and COVID-19 pandemic as a respiratory viral disease led to lung infection and resulted in millions of deaths. So, the impact of COVID-19 on asthma outcomes and the risk of being infected or hospitalized should be clarified. Systematic review and meta-analysis on the outcomes and risk of asthma for people with COVID-19 was done by searching electronic databases between 1 December 2019 and 31 July 2023. A total of 48 studies from 27 countries spread across all continents were included in the review. The prevalence of asthma among COVID-19 patients was 7.9%, and the analysis demonstrated a 16.5% reduction in the risk ratio for acquiring COVID-19 among subjects with asthma compared to those without asthma. There was no statistically significant difference in hospitalization risk, ICU admission risk, and death risk for COVID-19 patients with no asthma compared to those with asthma. The risk of death from COVID-19 was similar between nonasthmatics and asthmatics. The findings indicated that subjects with asthma may be at a lower risk of having infection with COVID-19 compared to those without asthma, but they have a similar risk of hospitalization and mortality.
References
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3. Hajimohammadi B, Athari SM, Abdollahi M, Vahedi G, Athari SS. Oral Administration of Acrylamide Worsens the Inflammatory Responses in the Airways of Asthmatic Mice through Agitation of Oxidative Stress in the Lungs. Frontiers in Immunol 2020;11:1940. 10.3389/fimmu.2020.01940
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5. Entezar MN, Siamak H, Bahram Y, Seyyed SA. Acute upper limb ischemia in a patient with COVID-19: A case report. Annals of Vasc Surg 2021;77:83–85. 10.1016/j.avsg.2021.07.007
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8. Ling Q, Entezar MN, Seyyede MA, Seyyed SA. Mitochondria signaling pathways in allergic asthma. J Investig Med 2022;70(4):863–882. 10.1136/jim-2021-002098
9. Entezar Mehrabi Nasab, Seyyed Shamsadin Athari. Reporting complete heart block in a patient with polyarteritis nodosa after COVID-19 vaccination. ESC Heart Failure 2023;10(2):1418–1421. 10.1002/ehf2.14227
10. Dong W, Entezar MN, Seyyed SA. Study effect of Baicalein encapsulated/loaded Chitosan-nanoparticle on allergic Asthma pathology in mouse model. Saudi J Biol Sci 2021;28:4311–4317. 10.1016/j.sjbs.2021.04.009
11. Jinan J, Entezar MN, Seyyede MA, Seyyed SA. Effects of vitamin E and selenium on allergic rhinitis and asthma pathophysiology. Respiratory Physiology & Neurobiology 2021;286:103614. 10.1016/j.resp.2020.103614
12. Zhiwei W, Entezar MN, Poonam A, Seyyed SA. Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway. Journal of Translational Medicine 2022;20:130. 10.1186/s12967-022-03337-3
13. Anthony PS, Sabine MA, Gian LDT, Christine RJ. Asthma and COVID-19 risk: a systematic review and meta--analysis. Eur Respir J 2022;59:2101209. 10.1183/13993003.01209-2021
14. Ouzzani M, Hammady H, Fedorowicz Z, et al. Rayyan–a web and mobile app for systematic reviews. Syst Rev 2016;5:210. 10.1186/s13643-016-0384-4
15. Wells G, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-analyses. 2020.
16. Caminati M, Vultaggio A, Matucci A, et al. Asthma in a large COVID-19 cohort: prevalence, features, and determinants of COVID-19 disease severity. Respir Med 2021;176:106261. 10.1016/j.rmed.2020.106261
17. Caliskan T, Saylan B. Smoking and comorbidities are associated with COVID-19 severity and mortality in 565 patients treated in Turkey: a retrospective observational study. Rev Assoc Med Bras 2020;66:1679–1684. 10.1590/1806-9282.66.12.1679
18. Patone M, Thomas K, Hatch R, et al. Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study. Lancet Infect Dis 2021;21:1518–1528. 10.1016/S1473-3099(21)00318-2
19. Cao L, Lee S, Krings JG, et al. Asthma in patients with suspected and diagnosed coronavirus disease 2019. Annal Allergy Asthma Immunol 2021;126:535–541. 10.1016/j.anai.2021.02.020
20. Green I, Merzon E, Vinker S, et al. COVID-19 susceptibility in bronchial asthma. J Allergy Clin Immunol Pract 2021;9:684–692. 10.1016/j.jaip.2020.11.020
21. Bedolla-Barajas M, Morales-Romero J, Bedolla-Pulido TR, et al. Low prevalence of asthma in Mexican children and adults with a positive rtRT-PCR test for SARS-CoV-2: a cross-sectional study during the 2020 pandemic. Al Immuno 2021;49:1–7. 10.15586/aei.v49i3.7
22. Ho KS, Howell D, Rogers L, et al. The relationship between asthma, eosinophilia, and outcomes in coronavirus disease 2019 infection. Ann Allergy Asthma Immunol 2021;127:42–48. 10.1016/j.anai.2021.02.021
23. Wark PAB, Pathinayake PS, Kaiko G, et al. ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma. Respirology 2021;26:442–451. 10.1111/resp.14003
24. Ramakrishnan S, Nicolau DV, Langford B, et al. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial. Lancet Respir Med 2021;9:763–772. 10.1016/S2213-2600(21)00212-5
25. Yu L-M, Bafadhel M, Dorward J, et al. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet. 2021;398(10303):843–855. 10.1016/S0140-6736(21)01744-X
26. Schönfeld D, Arias S, Bossio JC, et al. Clinical presentation and outcomes of the first patients with COVID-19 in Argentina: results of 207079 cases from a national database. PLoS One 2021;16:e0246793. 10.1371/journal.pone.0246793
27. Louie T, Kwan B, Susanto C, et al. Respiratory failure, clinical course and community management of COVID-19 patients in a large Australian cohort. Intern Med J 2021;51:334–340. 10.1111/imj.15206
28. Je D, O’Brolchain A, Ulett KB, et al. Demographics, clinical characteristics and outcomes among 197 patients with COVID-19 in the Gold Coast area. Intern Med J 2021;51:666–672. 10.1111/imj.15260
29. Calmes D, Graff S, Maes N, et al. Asthma and COPD are not risk factors for ICU stay and death in case of SARS-CoV2-infection. J Allergy Clin Immunol Pract 2021; 9:160–169. 10.1016/j.jaip.2020.09.044
30. Tutiya C, Mello F, Chaccur G, et al. Risk factors for severe and critical Covid-19 in pregnant women in a single center in Brazil. J Matern Fetal Neonatal Med. 2022;35(25):5389–5392. 10.1080/14767058.2021.1880561
31. Guan W-J, Liang W-H, Shi Y, et al. Chronic respiratory diseases and the outcomes of COVID-19: a nationwide retrospective cohort study of 39,420 cases. J Allergy Clin Immunol Pract 2021;9:2645–2655. 10.1016/j.jaip.2021.02.041
32. Wang J, Guo S, Zhang Y, et al. Clinical features and risk factors for severe inpatients with COVID-19: a retrospective study in China. PLoS One 2020;15:e0244125. 10.1371/journal.pone.0244125
33. Zhang JJ, Cao YY, Dong X, et al. Distinct characteristics of COVID-19 patients with initial rRT-PCR-positive and rRT-PCR-negative results for SARS-CoV-2. Allergy 2020;75:1809–1812. 10.1111/all.14316
34. Hansen ESH, Moeller AL, Backer V, et al. Severe outcomes of COVID-19 among patients with COPD and asthma. ERJ Open Res 2021;7:594–2020. 10.1183/23120541.00594-2020
35. Yordanov Y, Dinh A, Bleibtreu A, et al. Clinical characteristics and factors associated with hospital admission or death in 43 103 adult outpatients with coronavirus disease 2019 managed with the Covidom telesurveillance solution: a prospective cohort study. Clin Microbiol Infect 2021; 27;1158–1166. 10.1016/j.cmi.2021.04.010
36. Beurnier A, Jutant EM, Jevnikar M, et al. Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation. Eur Respir J 2020; 56:2001875. 10.1183/13993003.01875-2020
37. Ashinyo ME, Duti V, Dubik SD, et al. Clinical characteristics, treatment regimen and duration of hospitalization among COVID-19 patients in Ghana: a retrospective cohort study. Pan Afr Med J 2020;37:9. 10.11604/pamj.supp.2020.37.1.25718
38. Lombardi C, Roca E, Bigni B, et al. Clinical course and outcomes of patients with asthma hospitalized for severe acute respiratory syndrome coronavirus 2 pneumonia: a single--center, retrospective study. Ann Allergy Asthma Immunol 2020;125:707–709. 10.1016/j.anai.2020.07.029
39. Kipourou DK, Leyrat C, Alsheridah N, et al. Probabilities of ICU admission and hospital discharge according to patient characteristics in the designated COVID-19 hospital of Kuwait. BMC Public Health 2021;21:799. 10.1186/s12889-021-10759-z
40. Almazeedi S, Al-Youha S, Jamal MH, et al. Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait. EClinicalMedicine 2020;24:100448. 10.1016/j.eclinm.2020.100448
41. Aveyard P, Gao M, Lindson N, et al. Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study. Lancet Respir Med, 2021;9:909–923. 10.1016/S2213-2600(21)00095-3
42. Martos-Benítez FD, Soler-Morejón CD, García-Del Barco D. Chronic comorbidities and clinical outcomes in patients with and without COVID-19: a large population-based study using national administrative healthcare open data of Mexico. Intern Emerg Med 2021;16:1507–1517. 10.1007/s11739-020-02597-5
43. Murillo-Zamora E, Hernandez-Suarez CM. Survival in adult inpatients with COVID-19. Public Health 2021;190: 1–3. 10.1016/j.puhe.2020.10.029
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Jul 1, 2024
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Li, X., Sheng, D., Chen, K., & Wang, Q. (2024). Consequence of COVID-19 on allergic asthma outcomes: a systematic review and meta-analysis. Allergologia Et Immunopathologia, 52(4), 73-80. https://doi.org/10.15586/aei.v52i4.1116
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How to Cite
Li, X., Sheng, D., Chen, K., & Wang, Q. (2024). Consequence of COVID-19 on allergic asthma outcomes: a systematic review and meta-analysis. Allergologia Et Immunopathologia, 52(4), 73-80. https://doi.org/10.15586/aei.v52i4.1116